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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3464 | PHCCC | (-) PHCCC | GluR |
PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8. | |||
T1880 | P7C3 | Others | |
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... | |||
TQ0289 | LY450108 | iGluR | |
LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies. | |||
T2216 | Entacapone | OR-611 | Transferase |
Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). | |||
T1770 | GNE-9605 | LRRK2 | |
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM). | |||
T7729 | PF-06454589 | LRRK2 | |
PF-06454589 is a potent inhibitor of LRRK2. | |||
T6795 | Carbidopa | (S)-(-)-Carbidopa,Lodosyn | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. | |||
T22026 | AGK7 | Others , Sirtuin | |
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). | |||
T3278 | Piribedil | EU-4200,Trivastan,ET-495,Trivastal | Dopamine Receptor , Histone Methyltransferase , Adrenergic Receptor |
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease. | |||
T8737 | GR 125743 | 5-HT Receptor | |
GR 125743 is a novel antagonist of 5-HT1B/1D receptor. | |||
T1308 | Orphenadrine hydrochloride | Mebedrol,Mephenamin | Sodium Channel , NMDAR , Norepinephrine , iGluR , Histamine Receptor |
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | |||
T6830 | Epoxomicin | BU-4061T,BU-4061T,Aids010837 | Apoptosis , Proteasome |
Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited... | |||
T6726 | VU0361737 | ML-128,VU 0361737 | GluR |
VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity... | |||
T5139 | CZC-25146 hydrochloride | LRRK2 | |
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. | |||
T1476 | Pramipexole | SND 919 | Dopamine Receptor |
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... | |||
T3053 | CZC-25146 | CHEMBL2397014 | LRRK2 |
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively. | |||
T2148 | Carbidopa monohydrate | Carbidopa Hydrate,S(-)-Carbidopa | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. | |||
T0437 | Inosine | INO 495,NSC 20262 | ROS , Endogenous Metabolite , Adenosine Receptor |
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. | |||
T4979 | Procyclidine hydrochloride | (±)-Procyclidine hydrochlorid | NMDAR , iGluR |
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties. | |||
T0957 | Isradipine | PN 200-110 | Calcium Channel , Autophagy |
Isradipine (PN 200-110) is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calcium ion channels of coronary and peripheral vasc... |