Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 112.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 329.00 | |
50 mg | In stock | $ 492.00 | |
100 mg | In stock | $ 717.00 |
Description | CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. |
Targets&IC50 | LRRK2 (WT):4.76 nM, LRRK2 (G2019S):6.87 nM |
In vitro | CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro. |
In vivo | CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies. |
Molecular Weight | 525 |
Formula | C22H26ClFN6O4S |
CAS No. | 1330003-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (104.76 mM)
You can also refer to dose conversion for different animals. More
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