Home Tools
Log in
Cart

CZC-25146 hydrochloride

Catalog No. T5139   CAS 1330003-04-7

CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CZC-25146 hydrochloride Chemical Structure
CZC-25146 hydrochloride, CAS 1330003-04-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 112.00
10 mg In stock $ 198.00
25 mg In stock $ 329.00
50 mg In stock $ 492.00
100 mg In stock $ 717.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.06%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
Targets&IC50 LRRK2 (WT):4.76 nM, LRRK2 (G2019S):6.87 nM
In vitro CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro.
In vivo CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.
Molecular Weight 525
Formula C22H26ClFN6O4S
CAS No. 1330003-04-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (104.76 mM)

TargetMolReferences and Literature

1. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Autophagy Compound Library Bioactive Compound Library Inhibitor Library Anti-Parkinson's Disease Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library

Related Products

Related compounds with same targets
GNE0877 LRRK2 inhibitor 1 CCG-1423 JH-II-127 CZC-54252 hydrochloride GSK2578215A HG-10-102-01 GNE-9605

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CZC-25146 hydrochloride 1330003-04-7 Autophagy LRRK2 Leucine-rich repeat kinase 2 CZC25146 neurons CZC-25146 Hydrochloride LRRK2 G2019S CZC 25146 Inhibitor liver diseases inflammatory Parkinson's disease inhibit CZC-25146 CZC 25146 Hydrochloride CZC25146 Hydrochloride CZC 25146 hydrochloride CZC25146 hydrochloride inhibitor

 

TargetMol