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GNE-9605

Catalog No. T1770 CAS 1536200-31-3

GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).

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GNE-9605, CAS 1536200-31-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 333.00
50 mg	In stock	$ 493.00
100 mg	In stock	$ 732.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.75%

Purity: 98.69%

Purity: 98.55%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
Targets&IC50	LRRK2:19 nM
In vitro	In rats, PKGNE-9605 administered orally at a dose of 1 mg/kg exhibited a total plasma clearance rate of 26 mL/min/kg, achieving an oral bioavailability of 90%. In BAC transgenic mice models expressing the human LRRK2 G2019S mutation associated with Parkinson's disease, GNE-9605, administered intraperitoneally at doses of 10 and 50 mg/kg, was able to inhibit the autophosphorylation of LRRK2 at Ser1292.
In vivo	In vitro human MDR1 permeability data indicate that GNE-9605 exhibits favorable brain penetration in higher organisms. In biochemical (Ki: 2.0 nM) and cellular (IC50: 19 nM) assays, GNE-9605 demonstrates potent inhibitory activity against LRRK2.

Molecular Weight	449.83
Formula	C17H20ClF4N7O
CAS No.	1536200-31-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 82 mg/mL (182.3 mM)

Ethanol: 10 mg/mL (22.2 mM)

References and Literature

1. Estrada AA , et al. J Med Chem. 2014, 57(3), 921-936.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Glutamine Metabolism Compound Library Autophagy Compound Library Anti-Parkinson's Disease Compound Library Target-Focused Phenotypic Screening Library Fluorochemical Library Anti-Aging Compound Library CNS-Penetrant Compound Library

Related Products

Related compounds with same targets

GNE0877 CCG-1423 BIX 02565 CZC-54252 hydrochloride GSK2578215A HG-10-102-01 PF-06454589 CZC-54252

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNE-9605 1536200-31-3 Autophagy LRRK2 oral bioavailability Leucine-rich repeat kinase 2 Parkinson's disease LRRK2 Ser1292 GNE 9605 autophosphorylation Inhibitor GNE9605 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.