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AGK7

Catalog No. T22026 CAS 304896-21-7

AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = <5 μM, <50 μM and <50 μM for SIRT3, SIRT1, and SIRT2, respectively).

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AGK7, CAS 304896-21-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 65.00
5 mg	In stock	$ 125.00
10 mg	In stock	$ 215.00
25 mg	In stock	$ 454.00

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Purity: 98.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).

In vitro

AGK2 is a selective SIRT2 inhibitor with IC50 value of 3.5 μM. AGK2 slightly inhibited SIRT1 and 3 only at concentrations over 40 μM. Relative to an inactive control AGK7, AGK2 increased acetylated tubulin. In H4 cells transfected with α-Syn, AGK2 reduced α-Syn-mediated toxicity in a dose-dependent way. By contrast, the inactive AGK7 had no effect. In H4 cells cotransfected withα-Syn and synphilin-1, the inactive AGK7 failed to affect a-Syn aggregation, whereas AGK2 promoted the formation of enlarged inclusions [1].

Molecular Weight	434.27
Formula	C23H13Cl2N3O2
CAS No.	304896-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 0.5 mg/mL

References and Literature

1. Tiago Fleming Outeiro, et al.Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.Science. 2007 Jul 27;317(5837):516-9.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max NO PAINS Compound Library Epigenetics Compound Library Bioactive Compound Library

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Ginkgolide C Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) Z26395438 Resveratrol Splitomicin Selisistat R-enantiomer Nicotinamide riboside MDL-811

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AGK7 304896-21-7 Chromatin/Epigenetic DNA Damage/DNA Repair Others Sirtuin Parkinson's disease sirtuin 2 morphology SIRT2 Inhibitor,Inactive Control Drosophila inhibit toxicity Inhibitor alpha-synuclein dopaminergic cell death AGK 7 AGK-7 inhibitor

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