caco-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0265	Indolelactic acid		Endogenous Metabolite
	Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.		Endogenous Metabolite
T9927	Panitumumab		EGFR
	Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).		EGFR
T7210	Guanosine 5'-diphosphate	GDP	Endogenous Metabolite
	Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.		Endogenous Metabolite
T19676	Tributyrin	NSC661583,NSC 661583,NSC-661583	Apoptosis
	Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell...		Apoptosis
T2670	ML167	NCGC00188654,CID44968231	DYRK , CDK
	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.		DYRK , CDK
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
T0242L	Sitagliptin phosphate monohydrate	MK-0431,MK-0431 phosphate monohydrate	Proteasome , DPP-4 , Autophagy
	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.		Proteasome , DPP-4 , Autophagy
TN3967	Epieriocalyxin A		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
T3148	MK-571 sodium	L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor , LTR
	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ...		Leukotriene Receptor , LTR
TN1740	Homoeriodictyol		5-HT Receptor , transporter , Sodium Channel , Drug Metabolite
	Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotoni...
T34973	Tyrphostin 8	4-Hydroxybenzylidenemalononitrile	EGFR , GTPase
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances ...		EGFR , GTPase
T18957	D-Ala-Lys-AMCA hydrochloride		Others
	D-Ala-Lys-AMCA hydrochloride is a known substrate of proton-coupled oligopeptide transporter 1 (PEPT1) that emits blue fluorescence.		Others
T23358	Sitagliptin phosphate	Januvia,MK-0431 phosphate,Sitagliptin (phosphate)	DPP-4 , Autophagy
	Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.		DPP-4 , Autophagy
T5S0890	Oleandrin	Neriostene,Folinerin,Foliandrin	Apoptosis , ATPase , Potassium Channel , Sodium Channel
	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...		Apoptosis , ATPase , Potassium Channel , Sodium Channel
T36473	Trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In...
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T0242	Sitagliptin	MK0431	Proteasome , DPP-4 , Autophagy
	Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedion...		Proteasome , DPP-4 , Autophagy
T81910	L-Tryptophanylglycine
	L-Tryptophanylglycine (Trp-gly), a dipeptide, inhibits Ceronapril uptake in Caco-2 cells with an inhibition constant (K i) of 7.19 mM [1].
TN1386	Angelol A		Others
	Angelol A and angelol B are passive diffusion as the dominating process in Caco-2 cell monolayer model.		Others