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Sitagliptin phosphate monohydrate

Catalog No. T0242L CAS 654671-77-9

Synonyms: MK-0431 phosphate monohydrate, 西他列汀磷酸盐一水合物, MK-0431

Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

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Sitagliptin phosphate monohydrate, CAS 654671-77-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
Targets&IC50	DPP-4:19 nM
In vitro	The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3]

Synonyms	MK-0431 phosphate monohydrate, 西他列汀磷酸盐一水合物, MK-0431
Molecular Weight	523.32
Formula	C16H15F6N5O·H3PO4·H2O
CAS No.	654671-77-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 38 mg/mL (72.6 mM)

Ethanol: <1 mg/mL

DMSO: 93 mg/mL (177.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Thomas L et al. J Pharmacol Exp Ther. 2008; 325(1): 175-182. 2. Kim SJ et al. Diabetes. 2009; 58(3): 641-651.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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