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Vildagliptin

Catalog No. T1502 CAS 274901-16-5

Synonyms: LAF237, 维达列汀, 维格列汀, NVP-LAF 237

Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine.

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Vildagliptin, CAS 274901-16-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine.
Targets&IC50	DPP-4:2.3 nM

Synonyms	LAF237, 维达列汀, 维格列汀, NVP-LAF 237
Molecular Weight	303.406
Formula	C17H25N3O2
CAS No.	274901-16-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 56 mg/mL (184.6 mM)

DMSO: 56 mg/mL (184.6 mM)

H2O: 55 mg/mL (181.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Villhauer EB, et al. J Med Chem, 2003, 46(13), 2774-2789. 2. Duttaroy A, et al. Eur J Pharmacol, 2011, 650(2-3), 703-707. 3. Jin HY, et al. Arch Med Res, 2009, 40(7), 536-544. 4. JMiura K, et al. Horm Metab Res, 2010, 42(10), 731-735. 5. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

Citations

1. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.

Related compound libraries

This product is contained In the following compound libraries：

Autophagy Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Inhibitor Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-COVID-19 Compound Library Apoptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vildagliptin 274901-16-5 蛋白酶体凋亡泛素化细胞周期 Apoptosis DPP-4 Ferroptosis Proteasome Dipeptidyl Peptidase Inhibitor peptidase Caco-2 cells LAF237 dipeptidyl LAF 237 DPP-IV antihyperglycemic NVP-LAF 237 DPP LAF-237 inhibit inhibitor

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