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Homoeriodictyol

Catalog No. TN1740 CAS 446-71-9

Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.

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Homoeriodictyol, CAS 446-71-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 129.00
5 mg	In stock	$ 278.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 1,000.00

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Purity: 99.96%

Purity: 99.79%

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Description	Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.
In vitro	In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT). In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D-(+)-glucose, treatment with 100 μM Homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM Homoeriodictyol to human neural SH-SY5Y cells.
Source	Natural Products > Loranthaceae > Taxillus

Molecular Weight	302.28
Formula	C16H14O6
CAS No.	446-71-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells.PLoS One. 2017 Feb 13;12(2):e0171580.

Related compound libraries

This product is contained In the following compound libraries：

Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Natural Product Library for HTS Flavonoid Natural Product Library Selected Plant-Sourced Compound Library Bioactive Compounds Library Max Rare Natural Product Library

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Keywords

Homoeriodictyol 446-71-9 GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Sodium Channel transporter 5-HT Receptor Drug Metabolite Eriocitrin flavonoid inhibit metabolite Inhibitor inhibitor

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