Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 40.00 | |
10 mg | In stock | $ 57.00 | |
25 mg | In stock | $ 92.00 | |
50 mg | In stock | $ 133.00 | |
100 mg | In stock | $ 197.00 | |
500 mg | In stock | $ 493.00 |
Description | Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect. |
Targets&IC50 | EGFR:560 μM (IC50), Calcineurin phosphatase:21 μM (IC50) |
In vitro | Pretreated for 20 minutes at concentrations ranging from 10 to 100 μM, Tyrphostin 8 blocks Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1]. Additionally, at concentrations of 10-100 μM, Tyrphostin 8 induces a rapid and substantial increase in the basal O2 consumption of parotid acinar cells[1]. Furthermore, at a concentration of 100 μM, Tyrphostin 8 reduces parotid ATP content by approximately 90%[1]. In another context, Tyrphostin 8 enhances the apical-to-basolateral transport of insulin-transferrin conjugate by promoting transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayers[2]. |
In vivo | In Streptozotocin-induced diabetic rats, Tyrphostin 8 enhances the glucose-lowering effect of insulin-transferrin[2]. |
Synonyms | 4-Hydroxybenzylidenemalononitrile |
Molecular Weight | 170.17 |
Formula | C10H6N2O |
CAS No. | 3785-90-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (293.82 mM)
You can also refer to dose conversion for different animals. More
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Tyrphostin 8 3785-90-8 Angiogenesis GPCR/G Protein JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR GTPase 4-Hydroxybenzylidenemalononitrile inhibitor inhibit