Search Result

Search Results for " cyp1a1 "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T27109	CYP1A1 inhibitor 8a
	CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxi...
T5116	Iprodione		Others , Reactive Oxygen Species , Antifungal
	Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.		Others , Reactive Oxygen Species , Antifungal
T10270	BAY 2416964		Aryl Hydrocarbon Receptor
	BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 192, IC50: 341 nM). It has the potential for cancer treatment.		Aryl Hydrocarbon Receptor
T8729	3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one		P450
	DMU2105 is a specific CYP1B1 inhibitor(CYP1B1 and CYP1A1 with IC50 of 10 nM and 742 nM, respectively)		P450
T3585	TMS	(E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene	P450
	TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).		P450
T8728	DMU-2139		P450
	DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively).		P450
T23151	Phortress	NSC 710305	AhR
	Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activity.		AhR
T21507	7-Ethoxyresorufin	Resorufin ethyl ether	P450 , NO Synthase
	7-Ethoxyresorufin (Resorufin ethyl ether) (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.		P450 , NO Synthase
T7696	3-Cyano-7-ethoxycoumarin		Others
	3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .		Others
T3158L	Harman hydrochloride	Harmane hydrochloride(486-84-0 Free base)	P450
	Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.		P450
T21704	5-fluoro 203	5F-203,NSC-703786	Others
	5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells...		Others
T7088	Diflubenzuron	Dimilin,Difubenzuron,Larvakil,Difluron	P450
	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2...		P450
T3637	Pifithrin-β hydrobromide	Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis , p53
	Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder...		Ferroptosis , p53
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T2196	Fipronil	Fluocyanobenpyrazole,Termidor	P450 , GluCls , GABA Receptor
	Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat...		P450 , GluCls , GABA Receptor
T73040	CYP1B1-IN-4		P450
	CYP1B1-IN-4, a 2,4-diarylthiazole compound, exhibits selective inhibition of CYP1B1 (IC50=0.2 nM), demonstrating minimal cytotoxicity and high stability in human and rat liver microsomes [1].		P450
T73039	CYP1B1-IN-3
	CYP1B1-IN-3 is a potent, selective inhibitor of CYP1B1, exhibiting IC50 values of 6.6 nM for CYP1B1, 347.3 nM for CYP1A1, and >10000 nM for CYP1A2. It also impedes cell migration and invasion, and inhibits the P-gp, AKT/...
T9704	1-Ethynylpyrene		P450
	1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).		P450
T73042	CYP1B1-IN-5		P450
	CYP1B1-IN-5 is a selective and potent cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.CYP1B1-IN-5 can be used for the study of metabolism-related diseases.		P450
T32136	ICT2700	de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700
	ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.
T72552	Antitumor agent-88
	Antitumor agent-88, a competitive inhibitor of CYP1A1 (K i: 1.4 μM), demonstrates significant antimitotic activity by arresting cells in the G2/M phase and disrupting the microtubule network and cytoskeleton in CYP1A1-ex...
T12449	Phortress free base		Others
	Phortress free base is a P450 CYP1A1-activated antitumor prodrug with antitumor activity.		Others
T36793	Dolutegravir M1
	Dolutegravir M1 is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed primarily by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1. 1.Zhu, J., Wang, P., Li, F., et al.CYP1A1 and 1B1-mediated met...
T70257	Avitriptan HCl
	Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligan...
T72551	Antitumor agent-87
	Antitumor agent-87 is a potent compound with antitumoral activity, demonstrating a high affinity for CYP1A1, evidenced by a K i value of 0.23 µM. It exhibits antiproliferative effects and induces cell cycle arrest at the...
T35855	AAA
	AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-...
T36039	16α-Hydroxyestrone
	The naturally-occurring estrogens are estrone , estradiol , and estriol . 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochr...
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...

Compounds

CYP1A1 inhibitor 8a

Target: Others, Reactive Oxygen Species, Antifungal

BAY 2416964

T10270

Synonym:

Target: Aryl Hydrocarbon Receptor

3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one

Synonym: (E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene

Synonym: Resorufin ethyl ether

Target: P450, NO Synthase

3-Cyano-7-ethoxycoumarin

Synonym: Harmane hydrochloride(486-84-0 Free base)

Target: P450

5-fluoro 203

T21704

Synonym: 5F-203,NSC-703786

Target: Others

Diflubenzuron

T7088

Synonym: Dimilin,Difubenzuron,Larvakil,Difluron

Target: P450

Pifithrin-β hydrobromide

T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Sulfaphenazole

T4567

Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide

Target: P450, Antibacterial

Fipronil

T2196

Synonym: Fluocyanobenpyrazole,Termidor

Target: P450, GluCls, GABA Receptor

Synonym: de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700

Cat No.	Product Name	Synonyms	Targets
T8198	Visnagin		Others
	Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.		Others
T5786	TETRAHYDROPIPERINE	Cosmoperine	P450 , TRP/TRPV Channel
	Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.		P450 , TRP/TRPV Channel
T9328	Ellagic Acid Dihydrate		P450
	Ellagic Acid Dihydrate inhibit the CYP1A1-dependent activation of benzo[a]pyrene.		P450
T2949	Alizarin	Mordant Red 11,Anthraquinonic	P450
	Alizarin (Mordant Red 11), a red dye derived from the roots of plants of the madder genus, inhibits P450 isoform CYP1A1( IC50 = 6.2 μM), CYP1A2 (IC50 =10.0 μM )and CYP1B1(IC50 = 2.7 μM).		P450
T7472	7-Hydroxyflavone		P450
	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity		P450
T5S0669	Bergamottin	5-Geranoxypsoralen,Bergamotine,Bergaptin	P450
	1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice.		P450
T3668	Galangin	Norizalpinin,3,5,7-Trihydroxyflavone	ERK , P450 , NF-κB , Autophagy
	Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.		ERK , P450 , NF-κB , Autophagy
T11218	ε-Viniferin	epsilon-Viniferin	P450
	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.		P450
TN1724	Harmalol hydrochloride	Harmidol hydrochloride	P450 , Antioxidant
	Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits ...		P450 , Antioxidant
T5582	β-Apo-8'-carotenal	trans-β-apo-8'-carotenal,Apocarotenal	Others , P450
	β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressing), beverages, dairy products, and sweets.		Others , P450
TN1222	26-Deoxyactein	27-Deoxyactein,23-epi-26-Deoxyactein	NOS , CDK , NO Synthase
	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...		NOS , CDK , NO Synthase
T3736	Olivetol	5-Pentylresorcinol,5-n-Amylresorcinol	Cannabinoid Receptor , P450 , IκB/IKK
	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an...		Cannabinoid Receptor , P450 , IκB/IKK
TQ0276	Methysticin	DL-Methysticin,(±)-Methystici	P450
	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.		P450
T3776	Rhapontigenin	Protigenin	P450 , Antibacterial , Antifungal
	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...		P450 , Antibacterial , Antifungal
T13670L	(Z)-Ligustilide	cis-Ligustilide,Ligustilide A	Antibacterial
	(Z)-Ligustilide (Ligustilide A) , an active ingredient isolated from the medicinal plants Angelica acutiloba and Cnidium officinale, inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via...		Antibacterial

Natural Products

Target: P450, TRP/TRPV Channel

Ellagic Acid Dihydrate

Synonym: Mordant Red 11,Anthraquinonic

Synonym: 5-Geranoxypsoralen,Bergamotine,Bergaptin

Target: P450

Galangin

T3668

Synonym: Norizalpinin,3,5,7-Trihydroxyflavone

Target: ERK, P450, NF-κB, Autophagy

ε-Viniferin

T11218

Synonym: epsilon-Viniferin

Target: P450

Harmalol hydrochloride

TN1724

Synonym: Harmidol hydrochloride

Target: P450, Antioxidant

β-Apo-8'-carotenal

T5582

Synonym: trans-β-apo-8'-carotenal,Apocarotenal

Target: Others, P450

26-Deoxyactein

TN1222

Synonym: 27-Deoxyactein,23-epi-26-Deoxyactein

Target: NOS, CDK, NO Synthase

Olivetol

T3736

Synonym: 5-Pentylresorcinol,5-n-Amylresorcinol

Target: Cannabinoid Receptor, P450, IκB/IKK

Methysticin

TQ0276

Synonym: DL-Methysticin,(±)-Methystici

Target: P450, Antibacterial, Antifungal

(Z)-Ligustilide

T13670L

Synonym: cis-Ligustilide,Ligustilide A

Target: Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01182	CYP1A1 Protein, Human, Recombinant (His)	Human	E. coli
	CYP1A1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 63.7 kDa and the accession number is P04798.

CYP1A1 Protein, Human, Recombinant (His)

TMPH-01182

Species: Human

Expression System: E. coli