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26-Deoxyactein

Catalog No. TN1222 CAS 264624-38-6

Synonyms: 27-Deoxyactein, 23-epi-26-Deoxyactein

23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.

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26-Deoxyactein, CAS 264624-38-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 156.00
5 mg	In stock	$ 333.00
10 mg	In stock	$ 568.00
25 mg	In stock	$ 897.00
50 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 488.00

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Purity: 98.06%

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Description	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
In vitro	Black cohosh rhizomes were extracted with methanol/water and fractionated by solvent-solvent partitioning to yield three fractions: hexane, ethyl acetate and water. The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. This suggests that the extract contains a mixture of components with the more active (or more abundant) causing G1 arrest and the less active causing G2/M arrest. We then examined specific components in this extract. The triterpene glycoside fraction obtained by polyamide column chromatography, and the specific triterpene glycosides actein, 23-epi-26-Deoxyactein and cimiracemoside A, inhibited growth of the MCF7 human breast cancer cells and induced cell cycle arrest at G1[1]
Source	Natural Products > Ranunculaceae > Cimicifuga

Synonyms	27-Deoxyactein, 23-epi-26-Deoxyactein
Molecular Weight	660.83
Formula	C37H56O10
CAS No.	264624-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (105.93 mM)

References and Literature

1. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells.Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Kinase Inhibitor Library Anti-Pancreatic Cancer Compound Library Chinese Pharmacopoeia Natural Product Library Immunology/Inflammation Compound Library NO PAINS Compound Library Anti-Tumor Natural Product Library Bioactive Compound Library Natural Product Library for HTS Anti-Breast Cancer Compound Library

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Keywords

26-Deoxyactein 264624-38-6 Cell Cycle/Checkpoint Immunology/Inflammation NOS NO Synthase CDK Inhibitor 27-Deoxyactein 23-epi-26-Deoxyactein 26Deoxyactein inhibit 26 Deoxyactein inhibitor

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