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Methysticin
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Catalog No. TQ0276Cas No. 20697-20-5
Alias DL-Methysticin, (±)-Methystici
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
Methysticin
😃Good
Catalog No. TQ0276Alias DL-Methysticin, (±)-MethysticiCas No. 20697-20-5
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 663 € | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Methysticin, a major kavalactone extracted from kava, can induce CYP1A1. |
| In vivo | Methysticin (6 mg/kg) is administered orally once weekly for six months to 6-month-old transgenic APP/Psen1 mice. This treatment initiates activation of the Nrf2 pathway in the mice's hippocampus and cortex. Despite Methysticin not altering Aβ deposition in the brains of treated APP/Psen1 mice compared to controls, it significantly mitigates microgliosis, astrogliosis, and the secretion of pro-inflammatory cytokines TNF-α and IL-17A. Additionally, Methysticin markedly activates the Nrf2/ARE pathway specifically in the hippocampus and cortex, but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice, leading to a significant increase in the expression of both genes relative to untreated animals. |
| Alias | DL-Methysticin, (±)-Methystici |
| Molecular Weight | 274.27 |
| Formula | C15H14O5 |
| Cas No. | 20697-20-5 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: 1 mg/mL (3.65 mM), Sonication is recommended. DMSO: 5 mg/mL (18.23 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Sci Citations
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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