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Catalog No. TQ0276   CAS 20697-20-5
Synonyms: (±)-Methystici, DL-Methysticin

Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.

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Methysticin, CAS 20697-20-5
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
In vitro Methysticin triggers the most profound inducing effect on CYP1A1. Methysticin is able to activate the AhR signaling pathway. Hepa1c1c7 cells are treated with various concentrations of kava extract (0-50 μg/mL) and six kavalactones (0-100 μM) for 24 h. The results indicate that kava extract at concentrations up to 50 μg/mL and kavalactones up to 100 μM do not induce cell death. For the following studies, kava extract at 0.78-6.25 μg/mL and kavalactones at 0.78-25 μM, concentrations that cause no damage to cells, are used [1].
In vivo Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6-month-old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis, and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in significant activation of the Nrf2/ARE pathway in the hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals [2].
Synonyms (±)-Methystici, DL-Methysticin
Molecular Weight 274.27
Formula C15H14O5
CAS No. 20697-20-5


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 1 mg/mL (3.65 mM)

DMSO: 5 mg/mL (18.23 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li Y, et al. Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. Toxicol Sci. 2011 Dec;124(2):388-99. 2. Fragoulis A, et al. Oral administration of Methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. Redox Biol. 2017 Aug;12:843-853.

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Methysticin 20697-20-5 Metabolism P450 (±)-Methystici DL-Methysticin Inhibitor inhibitor inhibit