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Harmalol hydrochloride

Catalog No. TN1724 CAS 6028-07-5

Synonyms: Harmidol hydrochloride

Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.

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Harmalol hydrochloride Chemical Structure

Harmalol hydrochloride, CAS 6028-07-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 218.00
25 mg	In stock	$ 369.00
50 mg	In stock	$ 543.00
100 mg	In stock	$ 776.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits dioxin-mediated induction of CYP1A1 at both transcriptional and post-translational levels. Harmalol hydrochloride showed vasorelaxant activity in isolated rat thoracic aortic preparations preconstricted with phenylephrine or KCl. Harmalol hydrochloride has antioxidant activity.
Targets&IC50	H4 human glioblastoma:23.7 μM(IC50s), MAO-A:0.66 μM, DYRK1A:0.63 μM
In vitro	Harmalol (0.5-12.5 μM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.[1] Harmalol (25 μM) reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells.[2]

Synonyms	Harmidol hydrochloride
Molecular Weight	236.7
Formula	C12H13ClN2O
CAS No.	6028-07-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (380.2 mM), Sonication is recommended.

References and Literature

1. El Gendy MA, et al. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol. 2012;50(2):353-362. 2. Han E S, et al. Inhibition of Glutamate-Induced Change in Mitochondrial Membrane Permeability in PC12 cells by 1-Methylated β-carbolines. The Korean Society of Applied Pharmacology. 2003;11(2): 112-118. 3. Brierley DI, et al. Developments in harmine pharmacology--implications for ayahuasca use and drug-dependence treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(2):263-272. 4. Tse SY, et al. Antioxidative properties of harmane and beta-carboline alkaloids. Biochem Pharmacol. 1991;42(3):459-46 5. Tarpley M, et al. Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies. Eur J Pharm Sci. 2021;162:105821.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Traditional Chinese Medicine Monomer Library Bioactive Compounds Library Max Natural Product Library for HTS Alkaloid Natural Product Library Selected Plant-Sourced Compound Library

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Keywords

Harmalol hydrochloride 6028-07-5 Metabolism oxidation-reduction Antioxidant P450 Harmidol hydrochloride Harmidol Hydrochloride Harmalol Hydrochloride inhibitor inhibit

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