stromal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5751	Tigogenin		Others
	Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.		Others
T2567	Etonogestrel	3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite
	Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
T10803	CHMFL-KIT-033		c-Kit
	CHMFL-KIT-033 is an effective and selective c-KIT inhibitor with an IC50 value of 45 nM for c-KIT T670I mutant in gastrointestinal stromal tumors.		c-Kit
T5409	AZD3229		c-Kit
	AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel.		c-Kit
T1776	Plerixafor	JM3100,AMD 3100,AMD-3329	Virus Protease , HIV Protease , CXCR
	Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.		Virus Protease , HIV Protease , CXCR
T4605	NT157		IGF-1R , STAT
	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.		IGF-1R , STAT
T2820	Glycitin	Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside	Others , Influenza Virus , Antibacterial
	Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.		Others , Influenza Virus , Antibacterial
T17208	USL311		CXCR
	USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing...		CXCR
T8402	Regorafenib Hydrochloride	BAY73-4506 hydrochloride	Raf , VEGFR , c-RET , PDGFR , Autophagy
	Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity		Raf , VEGFR , c-RET , PDGFR , Autophagy
T3674	Hydroxysafflor yellow A	HSYA,Safflomin A	TGF-beta/Smad
	Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit...		TGF-beta/Smad
T1776L	Plerixafor octahydrochloride	JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl	Virus Protease , HIV Protease , CXCR
	Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a...		Virus Protease , HIV Protease , CXCR
T16686	Pyr10		TRP/TRPV Channel
	Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits...		TRP/TRPV Channel
T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T16104	ML-9		Myosin , Akt
	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...		Myosin , Akt
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T70062	Osteoprotegerin
	Osteoprotegerin is a soluble secreted member of the tumor necrosis factor receptor superfamily, inhibiting osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, leading...
T22859	Imatinib hydrochloride		Others
	Imatinib is a multi-target inhibitor of v-Abl, c-Kit, and PDGFR (IC50: 0.6 μM, 0.1 μM, and 0.1 μM, respectively). Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs), and...		Others
T71894	AZD3229 Tosylate
	AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal stromal tumors (GISTs).
T16103	ML-9 Free Base		Others
	ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal ...		Others
T40908	KLD-12
	KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondra...