Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
Description | ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation. |
In vitro | ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2]. |
Molecular Weight | 361.29 |
Formula | C15H18Cl2N2O2S |
CAS No. | 105637-50-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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ML-9 105637-50-1 PI3K/Akt/mTOR信号通路 细胞骨架 Akt Myosin viability STIM1 Inhibitor MLCK caspase ML 9 ML9 inhibit cardiomyocyte inhibitor