Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 34.00 | |
10 mg | In stock | $ 52.00 | |
25 mg | In stock | $ 97.00 | |
50 mg | In stock | $ 158.00 | |
100 mg | In stock | $ 235.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 37.00 |
Description | ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation. |
In vitro | ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2]. |
Molecular Weight | 361.29 |
Formula | C15H18Cl2N2O2S |
CAS No. | 105637-50-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (69.2 mM)
You can also refer to dose conversion for different animals. More
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ML-9 105637-50-1 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Myosin Akt viability STIM1 Inhibitor ML9 MLCK caspase inhibit ML 9 cardiomyocyte inhibitor