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Angiogenesis VEGFR Regorafenib Hydrochloride

Regorafenib Hydrochloride

Catalog No. T8402   CAS 835621-07-3
Synonyms: BAY73-4506 hydrochloride

Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Regorafenib Hydrochloride, CAS 835621-07-3
Pack Size Availability Price/USD Quantity
5 mg In stock 49.00
10 mg In stock 59.00
50 mg In stock 113.00
100 mg In stock 167.00
1 mL * 10 mM (in DMSO) In stock 64.00
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Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Regorafenib Hydrochloride is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
Targets&IC50 VEGFR1 ,   VEGFR2 ,   VEGFR3 ,   PDGFRβ ,   Braf ,   BRafV600E ,   Raf-1
Synonyms BAY73-4506 hydrochloride
Purity 100.00%
Molecular Weight 519.28
Formula C21H16Cl2F4N4O3
CAS No. 835621-07-3

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 5.6 mg/mL (10.78 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255. 2. Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Apoptosis Compound Library MAPK Inhibitor Library Tyrosine kinase inhibitor library FDA-approved Drug Library Kinase Inhibitor Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library Preclinical Compound Library Anti-aging Compound Library Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library HIF-1 Signaling Pathway Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-fibrosis Compound Library

Related Products

Related compounds with same targets
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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