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Regorafenib Hydrochloride

Regorafenib Hydrochloride
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Purity:100%
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Regorafenib Hydrochloride

Catalog No. T8402Cas No. 835621-07-3
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
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Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$47In Stock
25 mg$73In Stock
50 mg$97In Stock
100 mg$147In Stock
500 mg$369In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Product Introduction

Bioactivity
Description
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
In vitro
Regorafenib inhibits additional angiogenic kinases (VEGFR1/3, platelet-derived growth factor receptor-β and fibroblast growth factor receptor 1) and the mutant oncogenic kinases KIT, RET and B-RAF.
In vivo
Regorafenib administered once orally at 10 mg/kg significantly decreased the extravasation of Gadomer in the vasculature of rat GS9L glioblastoma tumor xenografts.?In a daily (qd)×4 dosing study, the pharmacodynamic effects persisted for 48 hr after the last dosing and correlated with tumor growth inhibition (TGI).?A significant reduction in tumor microvessel area was observed in a human colorectal xenograft after qd×5 dosing at 10 and 30 mg/kg.?Regorafenib exhibited potent dose-dependent TGI in various preclinical human xenograft models in mice, with tumor shrinkages observed in breast MDA-MB-231 and renal 786-O carcinoma models.?Pharmacodynamic analyses of the breast model revealed strong reduction in staining of proliferation marker Ki-67 and phosphorylated extracellular regulated kinases 1/2[1].
AliasBAY73-4506 hydrochloride
Chemical Properties
Molecular Weight519.28
FormulaC21H16Cl2F4N4O3
Cas No.835621-07-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 5.6 mg/mL (10.78 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9257 mL9.6287 mL19.2574 mL96.2872 mL
5 mM0.3851 mL1.9257 mL3.8515 mL19.2574 mL
10 mM0.1926 mL0.9629 mL1.9257 mL9.6287 mL

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