cytotoxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37341	N-Acetyltyramine		Antibacterial
	N-acetyltyramine is a metabolite of the biogenic amine tyramine . It enhances cytotoxicity of doxorubicin in resistant P388 murine leukemia cells with an IC50 value of 0.13 μg/ml compared with an IC50 value of 0.48 μg/ml...		Antibacterial
T9925	Ofatumumab		Others
	Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation		Others
TN1807	Isoverticine		BCL , Caspase
	Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.		BCL , Caspase
T0840	Methimazole	Tapazole,Thiamazole	Thyroid hormone receptor(THR)
	Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.		Thyroid hormone receptor(THR)
T9918	Daratumumab		Others
	Daratumumab is a human monoclonal antibody that targets CD38 a cell surface protein that is overexpressed on multiple myeloma MM) cells.		Others
T11685	Isolongifolene	(-)-Isolongifolene	Apoptosis , Others
	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative ...		Apoptosis , Others
T3594	ML346		HSP
	ML346 is a novel activator of Hsp70.		HSP
T2496	(Z)-Semaxinib	SU5416	VEGFR
	(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w...		VEGFR
T1753	D-64131		Microtubule Associated
	D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.		Microtubule Associated
T8320	J14	J-14	Reactive Oxygen Species
	J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death		Reactive Oxygen Species
T5399	GeA-69		PARP
	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).		PARP
T8235	L-732138		Neurokinin receptor
	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)		Neurokinin receptor
T8205	Norwogonin	5,7,8-Trihydroxyflavone	Virus Protease
	Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).		Virus Protease
T13951	UCB-9260		TNF
	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.		TNF
T4517	L189		DNA , DNA/RNA Synthesis
	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).		DNA , DNA/RNA Synthesis
T4337	PCI 29732	PCI29732,PCI-29732	Others , BCRP , BTK
	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.		Others , BCRP , BTK
T12871	Talmapimod	SCIO-469	p38 MAPK
	Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ...		p38 MAPK
TN1103	Diphyllin		ATPase , Proton pump , Influenza Virus , HIV Protease
	Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.		ATPase , Proton pump , Influenza Virus , HIV Protease
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
TP1444	Magainin 2		Antibacterial , Antibiotic , Antifungal
	Magainin II is a member of the antimicrobial peptides family		Antibacterial , Antibiotic , Antifungal