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L189

Catalog No. T4517 CAS 64232-83-3

L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).

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L189, CAS 64232-83-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 36.00
5 mg	In stock	$ 59.00
10 mg	In stock	$ 91.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 343.00
100 mg	In stock	$ 480.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).
Targets&IC50	DNA ligase I:5 µM, DNA ligase III:9 µM, DNA ligase IV:5 µM
In vitro	L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.

Molecular Weight	246.29
Formula	C11H10N4OS
CAS No.	64232-83-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL

H2O: Insoluble

DMSO: 50 mg/mL (203.01 mM)

References and Literature

1. Xi Chen, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Aging Compound Library Covalent Inhibitor Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Cell Cycle Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L189 64232-83-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis DNA TMZ inhibit DNA Ligase IV cancer DNA Ligase I DNA Ligase III L-189 L 189 DNA ligase cell death Inhibitor cytotoxicity inhibitor

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