Powder: -20°C for 3 years
In solvent: -80°C for 2 years
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
Description | PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. |
Targets&IC50 | BTK:8.2 nM |
In vitro | PCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the "gatekeeper” residue. In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition. |
Synonyms | PCI-29732, PCI29732 |
Molecular Weight | 371.444 |
Formula | C22H21N5O |
CAS No. | 330786-25-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: >53 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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PCI 29732 330786-25-9 蛋白酪氨酸激酶 离子通道 其他 血管生成 BCRP BTK Others cytotoxicity Bruton tyrosine kinase Inhibitor Btk ABCG2 reversible PCI29732 BCR inhibit B-cell oral Breast cancer resistance protein PCI-29732 inhibitor