anti-angiogenesis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4425	JK-P3		VEGFR
	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...		VEGFR
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T0724	Formononetin	Biochanin B,Flavosil,Formononetol	Apoptosis , FGFR
	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.		Apoptosis , FGFR
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
T0314	Hexylresorcinol	4-Hexylresorcinol	Apoptosis , Tyrosinase , Antibacterial , Parasite
	Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.		Apoptosis , Tyrosinase , Antibacterial , Parasite
T4586	(Rac)-Arnebin 1	beta, beta-dimethylacrylshikonin	Others
	(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.		Others
T2690	Tranilast	MK 341,SB 252218	RAAS , Prostaglandin Receptor
	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders.		RAAS , Prostaglandin Receptor
T7203	Oglufanide	L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR , HCV Protease , Endogenous Metabolite
	Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).		VEGFR , HCV Protease , Endogenous Metabolite
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
TN1143	1-O-Acetyl britannilactone		NF-κB , COX
	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling.		NF-κB , COX
T10117	3'-O-Acetylhamaudol		Others
	3'- O- Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.		Others
T9127	MYLS22		Others
	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp...		Others
TN1557	Decursinol angelate		ERK , VEGFR , PKC , JNK
	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...		ERK , VEGFR , PKC , JNK
T28077	MMPP		VEGFR , STAT
	MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.		VEGFR , STAT
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis
TN1891	Lupiwighteone		Apoptosis , BCL , PARP , Caspase
	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.		Apoptosis , BCL , PARP , Caspase
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial