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MYLS22

Catalog No. T9127 CAS 306959-01-3

MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression. It with anti-angiogenesis and anti-cancer activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MYLS22, CAS 306959-01-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 57.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 166.00
50 mg	In stock	$ 253.00
100 mg	In stock	$ 391.00
200 mg	In stock	$ 587.00
500 mg	In stock	$ 929.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression. It with anti-angiogenesis and anti-cancer activity.
In vivo	MYLS22 (10 mg/kg/die;?peritumoral injection;?every 2 days for 14 days) causes the tumor growth curtailed mice

Molecular Weight	443.52
Formula	C24H21N5O2S
CAS No.	306959-01-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (187.88 mM), Sonification is recommended.

References and Literature

1. Stéphanie Herkenne, et al. Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab. 2020 May 5;31(5):987-1003.e8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Angiogenesis related Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MYLS22 306959-01-3 Others OPA1 Inhibitor optic atrophy MYLS 22 endothelial inhibit tumor MYLS-22 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.