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NF-Κb NF-κB 1-O-Acetyl britannilactone

1-O-Acetyl britannilactone

Catalog No. TN1143   CAS 681457-46-5
Purity 98.00% Datasheet

1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling.

1-O-Acetyl britannilactone, CAS 681457-46-5
Pack Size Availability Price/USD Quantity
1 mg Inquiry 194.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description 1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling.
Targets&IC50 p65,   NF-κB,   COX,  
In vitro The content of the compound ABL in flowers crude extract was tested with high performance liquid chromatography.The inhibitory effects of compound ABL against Sphaerotheca fuliginea,Pseudoperonospora cubensis,Botrytis cinerea,Alternaria solani and Phytophthora infestans were tested.The chemical structure of ABL reference substance was elucidated by using ultraviolet spectrometry(UV),infrared spectroscopy(IR),nuclear magnetic resonance(NMR).The purity of ABL reference substance was 99.5%,which satisfies the need of reference substances of traditional Chinese medicines.A method of high performance liquid chromatography was used for the determination of the content of ABL in crude extract from I.japonica flowers(it's 2.45%),then the content of ABL in I.japonica was calculated(it's about 0.25%)[1]
Synonyms
Purity 98.00%
Appearance solid
Molecular Weight 308.37
Formula C17H24O5
CAS No. 681457-46-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Separation and analysis of 1-O-acetylbritannilactone from Inula japonica and determination of antifungal activityActa Phytophylacica Sinica, 2008 , 35 (6) :551-6. 2. 1-o-acetylbritannilactone Inhibits Inflammatory Response by Suppressing NF-κB ActivationChinese Journal of Cell Biology, 2007 , 29 (2) :267-71.

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