torin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...
T23183	(+)- Praeruptorin C		Others
	(+)- Praeruptorin C extracted from Peucedanum praeruptorum Dunn roots.
T33623	Necatorin	Necatorine
	Necatorin is a mutagenic compound from edible mushroom Lactarius necator.
T130965	Neosartorin
	Neosartorin is a useful organic compound for research related to life sciences and the catalog number is T130965.

Cat No.	Product Name	Synonyms	Targets
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
TN2024	Oxyimperatorin		Others
	Oxyimperatorin is a natural product from Angelica dahurica.		Others
T3777	Praeruptorin A	(+)-Praeruptorin A	CaMK , NF-κB
	Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or...		CaMK , NF-κB
T4S1419	(±)-Praeruptorin A	Praeruptorin A,(-)-Praeruptorin A	p38 MAPK , Calcium Channel , Akt
	1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ...		p38 MAPK , Calcium Channel , Akt
TN1369	Alloimperatorin	Prangenidin	Others
	Alloimperatorin (Prangenidin) exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficient...		Others
T2845	Imperatorin	Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen	TRP/TRPV Channel , AChR , AChE , NOD
	Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.		TRP/TRPV Channel , AChR , AChE , NOD
T2846	Isoimperatorin		Antibacterial , AChE
	Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).		Antibacterial , AChE
T8626	Transtorine	1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID	GluR , NMDAR
	Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) is a GluR and NMDA inhibitor.		GluR , NMDAR
T4S1422	Praeruptorin E		Others , Calcium Channel
	1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...		Others , Calcium Channel
T21165	Pellitorine	AI3-19560,Pellitorin	TRP/TRPV Channel
	Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.		TRP/TRPV Channel
T6S1423	Praeruptorin B		Others
	1. Praeruptorin B can inhibit tumor promoter induced phemonenon in vitro.		Others
TN1513	Clitorin		PKC , Antifection
	Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.		PKC , Antifection
T20604L	Litorin acetate(55749-97-8 Free base)		Bombesin Receptor
	Litorin acetate, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. It stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the n...		Bombesin Receptor
TN4819	(-)-Praeruptorin A		ATPase , IL Receptor , Calcium Channel , P-gp
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ...		ATPase , IL Receptor , Calcium Channel , P-gp
TN4039	Eupatorin-5-methylether		Others
	Eupatorin-5-methylether is a natural product for research related to life sciences. The catalog number is TN4039 and the CAS number is 21764-09-0.		Others
T11678	Iristectorin B		Others
	Iristectorin B has anti-cancer activities in breast cancer.is an isoflavone from Iris tectorum.		Others
TN3380	Alloisoimperatorin		AChR
	Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoi...		AChR
T13933	Toringin		Others
	Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies.		Others
TN1769	Iristectorin A		Others
	Iristectorin A is a natural product from Iris tectorum.		Others
T4S1421	Praeruptorin B	Praeruptorin D	NPC1L1 , Fatty Acid Synthase
	Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.		NPC1L1 , Fatty Acid Synthase
T32800	Littorine	(R)-(-)-Littorine
	Littorine is a tropane alkaloid found in a variety of plants including Datura and Atropa belladonna. It is closely related in chemical structure to atropine, hyoscyamine, and scopolamine, which all share a common biosynt...
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.

Natural Products

Eupatorin

Target: Antioxidant, Calcium Channel

Synonym: (+)-Praeruptorin A

Target: CaMK, NF-κB

(±)-Praeruptorin A

T4S1419

Synonym: Praeruptorin A,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

Synonym: Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen

Target: TRP/TRPV Channel, AChR, AChE, NOD

Isoimperatorin

T2846

Synonym:

Target: Antibacterial, AChE

Transtorine

T8626

Synonym: 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID

Target: Others, Calcium Channel

Pellitorine

T21165

Synonym: AI3-19560,Pellitorin

Target: TRP/TRPV Channel

Target: PKC, Antifection

Litorin acetate(55749-97-8 Free base)

T20604L

Synonym:

Target: Bombesin Receptor

(-)-Praeruptorin A

TN4819

Synonym:

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Eupatorin-5-methylether

Synonym: Praeruptorin D

Target: NPC1L1, Fatty Acid Synthase

Littorine

T32800

Synonym: (R)-(-)-Littorine

Cat No.	Product Name	Species	Expression System
TMPY-05169	Peroxiredoxin 2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Peroxiredoxin 2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24.1 kDa and the accession number is Q61171.

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