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Isoimperatorin

Catalog No. T2846 CAS 482-45-1

Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).

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Isoimperatorin, CAS 482-45-1

Pack Size	Availability	Price/USD
25 mg	In stock	$ 41.00
50 mg	In stock	$ 66.00
100 mg	In stock	$ 97.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.93%

Purity: 99.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE).
Targets&IC50	AChE:74.6 μM.
In vitro	The ethanol extract from Notopterygium incisum rhizomes displays significant nematicidal activity against nematodes Bursaphelenchus xylophilus and Meloidogyne incognita, discovered during a search for new agrochemicals from Chinese medicinal herbs. Four components—Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin—were isolated and identified from the extract via bioactivity-guided fractionation. Isoimperatorin exhibited notable efficacy with an LC50 value of 21.83 μg/mL against B. xylophilus. Under 15 min UV light exposure, Falcarindiol, Falcarinol, and Isoimperatorin showed nearly quintuple toxicity increase toward southern root-knot nematodes compared to dark conditions, whereas Columbianetin's toxicity doubled. Additionally, Isoimperatorin has been proven to have insecticidal properties against various insects, including the cabbage aphid (Brevicoryne brassicae). It has been found in the active fraction of Angelica dahurica (AD) extract and is frequently used as the internal standard (IS) in assays.
Source	Natural Products > Apiaceae > Cnidium

Molecular Weight	270.28
Formula	C16H14O4
CAS No.	482-45-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (37 mM), Sonification is recommended

References and Literature

1. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9. 2. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276. 3. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e20158796. 4. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Food as Medicine Compound Library Natural Product Library for HTS Anti-Fibrosis Compound Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library Traditional Mongolian Medicine Compound Library Natural Product Library

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Keywords

Isoimperatorin 482-45-1 Microbiology/Virology Neuroscience Antibacterial AChE inhibit Cholinesterase (ChE) Bacterial Inhibitor inhibitor

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