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Search Results for " sh-sy5y "

20

Compounds

Cat No. Product Name Synonyms Targets
T16550 PKR-IN-C16 Others
PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the A...
T2808 Bilobalide (-)-Bilobalide Apoptosis , Endogenous Metabolite , Autophagy
Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.
T7983 Isoborneol DL-Isoborneol HSV
Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities
T16079 Mirodenafil SK3530 PDE
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
T9079 Apostatin-1 Apt-1 Others
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
T2264 AM281 Cannabinoid Receptor
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
T0267 Zonisamide AD 810,CI 912 Calcium Channel , Sodium Channel , Carbonic Anhydrase
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...
T1567 Olanzapine LY170053 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
TQ0126 Mirodenafil dihydrochloride SK-3530 dihydrochloride PDE
Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
T1637 Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i...
T12352 Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.
T12352L Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
T39195 YM-244769 dihydrochloride Calcium Channel
YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.
T9888 YM-244769 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- Calcium Channel
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effec...
T27012 Chrysotoxine Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol NF-κB
Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
T7090 Jionoside A1 Others
Jionoside A1 is isolated and purified from the roots of Rehmannia glutinosa. It displays dose-dependent immune-enhancement activity and possesses moderate neuroprotective activities on H2O2-treated SH-SY5Y cells.
TN1891 Lupiwighteone Apoptosis , BCL , PARP , Caspase
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T8852 Tubuloside B Apoptosis , Others
The neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells.
T40063 CBR-470-1 Nrf2
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect...
T3803 Specnuezhenide Nuzhenide,Nuezhenide Others , NF-κB , Wnt/beta-catenin
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...

Compounds

PKR-IN-C16
T16550
Synonym:
Target: Others
Bilobalide
T2808
Synonym: (-)-Bilobalide
Target: Apoptosis, Endogenous Metabolite, Autophagy
Isoborneol
T7983
Synonym: DL-Isoborneol
Target: HSV
Mirodenafil
T16079
Synonym: SK3530
Target: PDE
Apostatin-1
T9079
Synonym: Apt-1
Target: Others
AM281
T2264
Synonym:
Target: Cannabinoid Receptor
Zonisamide
T0267
Synonym: AD 810,CI 912
Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase
Olanzapine
T1567
Synonym: LY170053
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR
Mirodenafil dihydrochloride
TQ0126
Synonym: SK-3530 dihydrochloride
Target: PDE
Deferoxamine Mesylate
T1637
Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM
Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy
Oxidopamine hydrochloride
T12352
Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride
Target: Mitophagy, Dopamine Receptor, Autophagy
Oxidopamine hydrobromide
T12352L
Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide
Target: Mitophagy, Dopamine Receptor, Autophagy
YM-244769 dihydrochloride
T39195
Synonym:
Target: Calcium Channel
YM-244769
T9888
Synonym: 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-
Target: Calcium Channel
Chrysotoxine
T27012
Synonym: Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-,4-[2-(3,4-Dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol
Target: NF-κB
Jionoside A1
T7090
Synonym:
Target: Others
Lupiwighteone
TN1891
Synonym:
Target: Apoptosis, BCL, PARP, Caspase
tubuloside B
T8852
Synonym:
Target: Apoptosis, Others
CBR-470-1
T40063
Synonym:
Target: Nrf2
Specnuezhenide
T3803
Synonym: Nuzhenide,Nuezhenide
Target: Others, NF-κB, Wnt/beta-catenin
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TargetMol