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Apostatin-1

Name: Apostatin-1
Brand: TargetMol
SKU: T9079
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9079Cas No. 2559703-06-7

Alias Apt-1

Apostatin-1 (Apt-1) is a novel TRADD inhibitor that binds to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Apostatin-1

🥰Excellent

Purity: 99.31%

Catalog No. T9079Alias Apt-1Cas No. 2559703-06-7

Apostatin-1 (Apt-1) is a novel TRADD inhibitor that binds to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$247	In Stock
50 mg	$397	In Stock
100 mg	$589	In Stock
500 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Batch Information

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Purity:99.31%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Apostatin-1 (Apt-1) is a novel TRADD inhibitor that binds to a pocket on the N-terminal TRAF2 binding domain of TRADD.
In vitro	Apostatin-1 inhibited bortezomib induced apoptosis and ripk1 dependent apoptosis (RDA) with the IC50 of ~1μM.
Synonyms	Apt-1

Chemical Properties

Molecular Weight	345.5
Formula	C₁₉H₂₇N₃OS
Cas No.	2559703-06-7
Smiles	CN1CCN=C1SC(C(=O)NC1CCCCCC1)c1ccccc1
Relative Density.	1.21 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (26.06 mM), Sonication is recommended.

DMSO: 50 mg/mL (144.72 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8944 mL	14.4718 mL	28.9436 mL	144.7178 mL
5 mM	0.5789 mL	2.8944 mL	5.7887 mL	28.9436 mL
10 mM	0.2894 mL	1.4472 mL	2.8944 mL	14.4718 mL
20 mM	0.1447 mL	0.7236 mL	1.4472 mL	7.2359 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0579 mL	0.2894 mL	0.5789 mL	2.8944 mL
100 mM	0.0289 mL	0.1447 mL	0.2894 mL	1.4472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc