nm-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T33701	NM-3	NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis , Reactive Oxygen Species
	NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the p...		Apoptosis , Reactive Oxygen Species
TQ0132	A 419259 trihydrochloride	RK 20449 trihydrochloride	Src
	A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).		Src
T10718L	CCT241533 hydrochloride		Chk
	CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).		Chk
T10708	CCR1 antagonist 6		CCR
	CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).		CCR
T10740	CDK8-IN-1		CDK
	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).		CDK
T14681	BMS-935177		BTK
	BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.		BTK
T2272	BPR1J-097	BPR1J097	FLT
	BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).		FLT
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
TQ0187	SR-3677		ROCK , Autophagy
	SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).		ROCK , Autophagy
T6756	AMG 925		FLT , CDK
	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.		FLT , CDK
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T10244	ACY-1083		HDAC
	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy.		HDAC
T7202	ITE		AhR , Aryl Hydrocarbon Receptor
	ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.		AhR , Aryl Hydrocarbon Receptor
T2251	NVP-TAE 684	TAE684	Apoptosis , ALK
	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).		Apoptosis , ALK
T11696	Ivachtin	Caspase-3 Inhibitor VII	Caspase
	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.		Caspase
TP1380	Galanin (1-16), mouse, porcine, rat		Neuropeptide Y Receptor
	Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons.		Neuropeptide Y Receptor
TQ0031	Nedisertib	M3814	DNA-PK
	Nedisertib (M3814) (M3814) is a specific inhibitor of DNA-dependent Protein Kinase (DNA-PK, IC50: <3 nM).		DNA-PK
T2710	TCS 1102		OX Receptor
	TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).		OX Receptor
TQ0263	EPZ031686	EPZ-031686	Histone Methyltransferase
	EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.		Histone Methyltransferase
T6309	AZ960	AZ 960	Apoptosis , Virus Protease , JAK , Parasite
	AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).		Apoptosis , Virus Protease , JAK , Parasite