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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1112 | Morellic acid | Others | |
Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity. | |||
T9979 | VEGFR-2-IN-29 | VEGFR | |
VEGFR-2-IN-29 is a VEGFR2 inhibitor. | |||
T11520 | GW806742X | MLK , VEGFR | |
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. | |||
T4435 | E7820 | ER68203-00 | Integrin |
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells). | |||
T4425 | JK-P3 | VEGFR | |
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format... | |||
T7611 | ODM-203 | VEGFR , FGFR | |
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity | |||
T22436 | Takeda-6d | VEGFR | |
Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM. | |||
T0692 | Allopurinol | Zyloric,Zyloprim,Lopurin | ROS , Xanthine Oxidase |
Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor. | |||
T6182 | Tirofiban | L700462,Aggrastat,MK383 | Integrin |
Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. | |||
T3982 | Vulpinic Acid | Vulpic acid,Pulvinic acid methyl ester | Others |
Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor. | |||
T6376 | Allopurinol Sodium | Allopurinol sodium salt,Sodium allopurinol | ROS |
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM. | |||
T2P2870 | Damascenone | trans-damascenone,Beta-Damascenone | Others , NF-κB , Endogenous Metabolite |
Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes. | |||
T2537 | Tirofiban hydrochloride monohydrate | Tirofiban Hydrochloride,MK-383 Hydrochloride | ATPase , Integrin |
Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist. | |||
T11076 | Dooku1 | Others | |
Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod... | |||
T0005 | Aspirin | Acetylsalicylate,Acetylsalicylic Acid,ASA | Mitophagy , Virus Protease , COX , Autophagy |
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel... | |||
T2500 | Cediranib | AZD2171,NSC-732208 | VEGFR , FLT , PDGFR , c-Kit , Autophagy |
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit... | |||
T10680 | Carebastine | Histamine Receptor | |
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. | |||
T3402 | 20(S)-Ginsenoside Rg3 | 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 | EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite |
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c... | |||
T6S1784 | Brazilin | Natural Red 24,Braziletto,Brasilin,Superbresiline | Apoptosis , Others , AMPK , Autophagy |
1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign... | |||
T3923 | Calycosin | Cyclosin,3'-Hydroxyformononetin | Apoptosis , Tyrosinase |
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... |