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Allopurinol

Name: Allopurinol
Brand: TargetMol
SKU: T0692
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0692Cas No. 315-30-0

Alias Zyloric, Zyloprim, Lopurin

Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.

Allopurinol

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Purity: 99.96%

Catalog No. T0692Alias Zyloric, Zyloprim, LopurinCas No. 315-30-0

Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$50	-	In Stock
10 g	$65	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Allopurinol AI Summary

Allopurinol is a notable xanthine oxidase inhibitor with an IC50 value of 2,000 nM, indicating its efficacy in reducing uric acid production. This enzyme plays a key role in purine metabolism and its inhibition can potentially be beneficial for managing conditions like gout, characterized by high uric acid levels. Furthermore, Allopurinol demonstrates favorable pharmacokinetic properties, including a volume of distribution of 0.6 L/kg and a high unbound fraction in plasma (Fu = 0.95) and tissues (Fu = 0.88), suggesting significant pharmacological activity and good tissue penetration. The compound is also soluble in water, with a Log S value of -2.26, and exhibits antioxidant activity by inhibiting superoxide anion production with an inhibition rate of 84.0% at 20 µg/mL. Additionally, it shows antihyperuricemic effects in animal models, further underscoring its therapeutic potential in the treatment of hyperuricemia and related disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
Targets&IC50	XO:7.82±0.12 μM
In vitro	10 mM Allopurinol inhibited the activity of oxygen xanthine oxidase produced by hypoxia-reoxygenation injury.Allopurinol reduced intracellular Ca2+ concentration by enhancing xanthine oxidase activity.Allopurinol reversed the increase in xanthine oxidase activity in neonatal rat hearts with ischemia-reperfusion injury.
In vivo	10 mM Allopurinol inhibited the activity of oxygen xanthine oxidase produced by hypoxia-reoxygenation injury.Allopurinol reduced intracellular Ca2+ concentration by enhancing xanthine oxidase activity.Allopurinol reversed the increase in xanthine oxidase activity in neonatal rat hearts with ischemia-reperfusion injury.
Synonyms	Zyloric, Zyloprim, Lopurin

Chemical Properties

Molecular Weight	136.11
Formula	C₅H₄N₄O
Cas No.	315-30-0
Smiles	OC1=NC=NC2=C1C=NN2
Relative Density.	1.4295 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3 mg/mL (22.04 mM), Sonication is recommended.

H2O: Insoluble

DMSO: 16.4 mg/mL (120.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (3.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3470 mL	36.7350 mL	73.4700 mL	367.3499 mL
5 mM	1.4694 mL	7.3470 mL	14.6940 mL	73.4700 mL
10 mM	0.7347 mL	3.6735 mL	7.3470 mL	36.7350 mL
20 mM	0.3673 mL	1.8367 mL	3.6735 mL	18.3675 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1469 mL	0.7347 mL	1.4694 mL	7.3470 mL
100 mM	0.0735 mL	0.3673 mL	0.7347 mL	3.6735 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc