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GW806742X

GW806742X
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
Catalog No. T11520Cas No. 579515-63-2
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Purity:98.30%
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GW806742X

Catalog No. T11520Cas No. 579515-63-2
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
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Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$47In Stock
10 mg$64In Stock
25 mg$122In Stock
50 mg$198In Stock
100 mg$367In Stock
1 mL x 10 mM (in DMSO)$60In Stock
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Product Introduction

Bioactivity
Description
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
Targets&IC50
MLKL:(kd)9.3 μM
In vitro
GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used.
Chemical Properties
Molecular Weight573.55
FormulaC25H22F3N7O4S
Cas No.579515-63-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (217.94 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7435 mL8.7176 mL17.4353 mL87.1764 mL
5 mM0.3487 mL1.7435 mL3.4871 mL17.4353 mL
10 mM0.1744 mL0.8718 mL1.7435 mL8.7176 mL
20 mM0.0872 mL0.4359 mL0.8718 mL4.3588 mL
50 mM0.0349 mL0.1744 mL0.3487 mL1.7435 mL
100 mM0.0174 mL0.0872 mL0.1744 mL0.8718 mL

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