Powder: -20°C for 3 years
In solvent: -80°C for 2 years
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
Description | GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. |
Targets&IC50 | MLKL:(kd)9.3 μM |
In vitro | GW806742X (1 μM) retards MLKL translocation to the membrane.GW806742X (0.1-10000 nM) rescues 50% of wild-type mouse dermal fibroblasts (MDFs) from TSQ-induced necroptosis with an IC50< 50 nM when 1 ng/mL TNF is used. |
Molecular Weight | 573.55 |
Formula | C25H22F3N7O4S |
CAS No. | 579515-63-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (217.94 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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GW806742X 579515-63-2 MAPK信号通路 蛋白酪氨酸激酶 血管生成 VEGFR MLK death translocation GW-806742X Vascular endothelial growth factor receptor membrane Inhibitor TSQ MLKs inhibit HUVEC Mixed Lineage Kinase necroptotic inhibitor