Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 67.00 | |
25 mg | In stock | $ 123.00 | |
50 mg | In stock | $ 217.00 | |
100 mg | In stock | $ 393.00 | |
500 mg | In stock | $ 937.00 |
Description | Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM. |
Targets&IC50 | GPIIb/IIIa:9 nM |
In vitro | Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. [1][2] It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μMol/L. [3] |
In vivo | Tirofiban (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. [4] When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. [5][6] |
Synonyms | L700462, Aggrastat, MK383 |
Molecular Weight | 440.6 |
Formula | C22H36N2O5S |
CAS No. | 144494-65-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tirofiban 144494-65-5 Cytoskeletal Signaling Integrin VEGF AMI MK-383 Inhibitor inhibit L700462 ACSs antithrombotic L 700462 Aggrastat HAEC MK 383 HUVEC L-700462 MK383 inhibitor