Search Result

Search Results for " db "

269

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T27124	DB-959 (salt)	T3D959,T-3D-959,T-3D959,DB-959Na,DB959Na
	DB-959, a PPAR agonist, is used potentially for the treatment of Alzheimer's disease.
T69674	DB-310
	DB-310 is a novel LMP2 inhibitor as a potential treatment for Alzheimer's disease.
T31215	DB-766	DB766
	DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y stra...
T24421	LY-2624803	DB-7,LY2624803,HY-10275,LY 2624803	5-HT Receptor , Histamine Receptor
	LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep.		5-HT Receptor , Histamine Receptor
T23967	DB-959 (free base)
	DB-959 is a potential agonist of PPAR.
T77925	DB-0646		PROTACs
	DB-0646 is a PROTAC designed to induce the degradation of multiple kinases.		PROTACs
T74101	DB-3-291
	DB-3-291 is potent and selective CSK degrader, with a K d of 1 nM [1] .
T31425	Dibenz[a,h]anthracene	CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A	DNA
	Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.		DNA
T10964	DB1976		Apoptosis , Others
	DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA comp...		Apoptosis , Others
T3200	DB07268		JNK
	DB07268 is a potent and selective JNK1 inhibitor.		JNK
T64372	DB722		Others
	DB722 is a furamidine analogues with DNA binding activity. DB722 shows antiproliferative activity.		Others
T23966	DB772	DB 772,DB-772
	DB772 is a scrapie prion accumulation inhibitor.
T24587	Pafuramidine maleate	DB-289,DB289,DB 289
	Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.
T15055	DB04760	MMP-13 Inhibitor	MMP
	DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.		MMP
T9707	DB2313	Carboximidamide	Apoptosis
	DB2313 (Carboximidamide) is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, an...		Apoptosis
T26003	Pyrazinobutazone	DB139,Carudol,DB-139,Ranoroc,DB 139
	Pyrazinobutazone is an antipyrene derivative which possesses anti-inflammatory properties.
T31891	Furidarone	DB 136,Furidarona,Furidaronum
	Furidarone is a biochemical.
T24414	Lofepramine hydrochloride	WHR-2908A,DB-2182,WHR 2908A
	Lofepramine is a serotonin and norepinephrine reuptake inhibitor. Lofepramine is also a psychotropic IMIPRAMINE derivative.
Fr13634	4-Aminobenzamide
	Compound Fr13634 is a useful organic compound for research related to life sciences. The catalog number is Fr13634 and the CAS number is 2835-68-9.
T23898	Clocoumarol	Clocoumarolum,BRN 1264788,DB 112
	Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes.
T23994	Dibenzo(a,i)pyrene	DB(a,i)p,Benzo(rst)pentaphene
	Dibenzo(a, i)pyrene is a polycyclic aromatic hydrocarbon with potent carcinogenic activity.
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T27395	Furamidine dihydrochloride	DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
	Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site ...
T32737	Liafensine	BMS820836,BMS 820836,DB104,BMS-820836	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T68487	DB1055
	DB1055 is a novel HOXA9 Transcription Factor Inhibitor, dedemonstrating for the first time the propensity of sequence-selective DNA ligands to inhibit HOXA9/DNA binding.
T15056	DB07107		Akt
	DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).		Akt
T68359	DB1255
	DB1255 is a ERG/DNA binding inhibitor which targets the DNA-binding activity of the human ERG transcription factor.
T10964L	DB1976 dihydrochloride	DB1976 hydrochloride,DB1976 2HCl	Apoptosis , NF-κB
	DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in i...		Apoptosis , NF-κB
T9958	DB818		Others
	DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.		Others
T71583	Amlodipine hydrochloride, (R)-
	Amlodipine hydrochloride, (R)-, is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vess...
T71585	DB03417
	DB03417 is a compound listed in web page: https://go.drugbank.com/drugs/DB03417. DB03417 is a potential tryptase inhibitor.
T69857	DB293
	DB293 is an inhibitor of PIT-1 and BRN-3 transcription factors. DB293 binds as head-to-tail stacked dimers in the minor groove of 5'-ATGA sequence, thereby leading to an increase in the size of minor groove.
T16428	Pafuramidine	DB289	Others
	Pafuramidine is an orally bioavailable prodrug of furamidine. It has activity against Pneumocystis pneumonia (IC50 value: 4.5 nM)		Others
T69841	GC813 sodium
	GC813 is a potent and permeable inhibitor of MERS coronavirus 3CL protease. GC813 is analogue of GC376.
T69856	Pralurbactam
	Pralurbactam is a β-Lactamase inhibitor utilized in the research of bacterial infections.
T69673	Deucrictibant
	Deucrictibant is a bradykinin receptor antagonist.
T11338	Furamidine	DB75,NSC 305831	Others
	Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...		Others
T38778	DB2115 tertahydrochloride	DB2115 tertahydrochloride
	DB2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator PU.1. With significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked ...
T19272	DB04760 analog 1		Others
	DB04760 analog 1 is an analogue of DB04760.		Others
T69354	Enzastaurin 2HCl
	Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein ki...
T71853	Enzastaurin HCl
	Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kina...
T27933	LY243246	LY249543 disodium,LY249543 sodium,LY 249543,LY-249543,S-isomer of lometrexol,DB04322,LY249543
	LY249543, the S-isomer of lometrexol, is an inhibitor of Methylenetetrahydrofolate Dehydrogenase/Cycl.
T4346	SPDB		Others
	SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.		Others
T1969	DBEQ	JRF 12	Apoptosis , p97 , Autophagy
	DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.		Apoptosis , p97 , Autophagy
T31221L	dBRD9 HCl	dBRD9 HCl(2170679-45-3 Free base)	Epigenetic Reader Domain
	dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl do...		Epigenetic Reader Domain
T15079	DBPR108		Proteasome , DPP-4
	DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.		Proteasome , DPP-4
T10965	DBPR112		EGFR
	DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy the ATP-binding site. DBPR112 has significant antitumor eff...		EGFR
T15069	DBCO-PEG4-Biotin	ADIBO-NH-PEG2-Biotin	Others
	DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) is an azadibenzocyclooctyne-biotin derivative containing a biotin moiety and 4 PEGs.DBCO-PEG4-Biotin is a versatile biotinylation reagent that introduces a portion of biotin into ...		Others
T22070	DBIBB		LPA Receptor
	DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra...		LPA Receptor
T15076	DBCO-S-S-PEG3-biotin		Others , PROTAC Linker
	DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents s...		Others , PROTAC Linker

Compounds

DB-959 (salt)

T27124

Synonym: T3D959,T-3D-959,T-3D959,DB-959Na,DB959Na

Synonym: DB-7,LY2624803,HY-10275,LY 2624803

Target: 5-HT Receptor, Histamine Receptor

Dibenz[a,h]anthracene

T31425

Synonym: CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A

Target: Apoptosis, Others

Synonym: DB 772,DB-772

Target:

Pafuramidine maleate

T24587

Synonym: DB-289,DB289,DB 289

Target:

DB04760

T15055

Synonym: MMP-13 Inhibitor

Target: MMP

DB2313

T9707

Synonym: Carboximidamide

Target: Apoptosis

Pyrazinobutazone

T26003

Synonym: DB139,Carudol,DB-139,Ranoroc,DB 139

Target:

Furidarone

T31891

Synonym: DB 136,Furidarona,Furidaronum

Target:

Lofepramine hydrochloride

T24414

Synonym: WHR-2908A,DB-2182,WHR 2908A

Synonym: Clocoumarolum,BRN 1264788,DB 112

Target:

Dibenzo(a,i)pyrene

T23994

Synonym: DB(a,i)p,Benzo(rst)pentaphene

Target:

Rilpivirine

T2330

Synonym: TMC278,R278474,DB08864

Target: HIV Protease, Reverse Transcriptase

Furamidine dihydrochloride

T27395

Synonym: DB 75, DB75, NSC 305831, WR199385,Furamidine HCl

Target:

Liafensine

T32737

Synonym: BMS820836,BMS 820836,DB104,BMS-820836

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

DB1976 dihydrochloride

T10964L

Synonym: DB1976 hydrochloride,DB1976 2HCl

Target: Apoptosis, NF-κB

Amlodipine hydrochloride, (R)-

Synonym: DB75,NSC 305831

Target: Others

DB2115 tertahydrochloride

T38778

Synonym: DB2115 tertahydrochloride

Synonym: LY249543 disodium,LY249543 sodium,LY 249543,LY-249543,S-isomer of lometrexol,DB04322,LY249543

Target: Apoptosis, p97, Autophagy

dBRD9 HCl

T31221L

Synonym: dBRD9 HCl(2170679-45-3 Free base)

Target: Epigenetic Reader Domain

DBPR108

T15079

Synonym:

Target: Proteasome, DPP-4

Synonym: ADIBO-NH-PEG2-Biotin

Target: Others, PROTAC Linker

Cat No.	Product Name	Targets
TN3484	Bakkenolide Db	Others
	Bakkenolide Db may have cytotoxicity.	Others
T80779	WDB002
	WDB002, a natural product belonging to the FK506/rapamycin family, targets CEP250 and may be employed in COVID-19 research [1].
T3414	Morroniside	Apoptosis , MMP , Pyroptosis
	Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib...	Apoptosis , MMP , Pyroptosis
T38250	L-Sepiapterin
	L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrat...
TN3532	Borapetoside E	Others
	Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.	Others
T5706	8-epidiosbulbin E acetate	Others
	8-epidiosbulbin E acetate is an abundant diterpene lactone in Dioscorea bulbifera L. (DB), a traditional herbal medicine widely used in Asian countries.	Others
TN3779	De-O-methyllasiodiplodin	IL Receptor , TNF , ROS , Antifection
	De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively ...	IL Receptor , TNF , ROS , Antifection

Natural Products

Target: Apoptosis, MMP, Pyroptosis

8-epidiosbulbin E acetate

T5706

Synonym:

Target: Others

De-O-methyllasiodiplodin

TN3779

Synonym:

Target: IL Receptor, TNF, ROS, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00411	LEPR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LEPR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 150-180 KDa and the accession number is P48357.
TMPJ-00976	LEPR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-10His tag. The predicted molecular weight is 120-150 KDa and the accession number is P48356.
TMPJ-00977	LEPR Protein, Mouse, Recombinant (mFc)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPJ-00975	LEPR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPH-02973	VDB Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. VDB Protein, Mouse, Recombi...
TMPH-00890	DBI Protein, Human, Recombinant (aa 2-104, His)	Human	E. coli
	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPJ-00759	VDB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Vitamin D-Binding Protein (DBP) is a member of the ALB/AFP/VDB family. DBP is a secreted protein and contains three albumin domains. The primary structure contains 28 cysteine residues forming multiple disulfide bonds. D...
TMPY-05552	DBT Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	DBT Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 48.8 kDa and the accession number is P11182.
TMPH-02178	TARDBP Protein, Human, Recombinant	Human	E. coli
	TARDBP Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 44.9 kDa and the accession number is Q13148.
TMPH-02972	VDB Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. VDB Protein, Mouse, Recombi...
TMPH-02179	TARDBP Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	TARDBP Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 44.9 kDa and the accession number is Q13148.
TMPH-03561	LsdB Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays i...
TMPH-03235	DBI Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPY-03991	DBI Protein, Human, Recombinant (His)	Human	E. coli
	The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece...
TMPH-02492	DBI Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site lo...
TMPK-00839	ITGB6 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide ...
TMPK-01247	ITGB6 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide ...