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Furamidine dihydrochloride

Catalog No. T27395 CAS 55368-40-6

Synonyms: DB 75, DB75, NSC 305831, WR199385, Furamidine HCl

Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furthermore, Furamidine blocks cell proliferation in leukemia cell lines with different genetic lesions.

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Furamidine dihydrochloride Chemical Structure

Furamidine dihydrochloride, CAS 55368-40-6

Pack Size	Availability	Price/USD
1 mg	35 days	$ 78.00
5 mg	35 days	$ 233.00
10 mg	35 days	$ 423.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

PRMT5:166 µM (IC50), PRMT1:9.4 μM (IC50), PRMT4:>400 µM (IC50), PRMT6:283 µM (IC50)

Synonyms	DB 75, DB75, NSC 305831, WR199385, Furamidine HCl
Molecular Weight	377.27
Formula	C18H18Cl2N4O
CAS No.	55368-40-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sauer B, Skinner-Adams TS, Bouchut A, Chua MJ, Pierrot C, Erdmann F, Robaa D, Schmidt M, Khalife J, Andrews KT, Sippl W. Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. Eur J Med Chem. 2017 Feb 15;127:22-40. doi: 10.1016/j.ejmech.2016.12.041. Epub 2016 Dec 23. PubMed PMID: 28038325. 2. Yang G, Choi G, No JH. Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6828-6836. doi: 10.1128/AAC.01129-16. Print 2016 Nov. PubMed PMID: 27600039; PubMed Central PMCID: PMC5075092. 3. Siboni RB, Bodner MJ, Khalifa MM, Docter AG, Choi JY, Nakamori M, Haley MM, Berglund JA. Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models. J Med Chem. 2015 Aug 13;58(15):5770-80. doi: 10.1021/acs.jmedchem.5b00356. Epub 2015 Jul 21. PubMed PMID: 26103061; PubMed Central PMCID: PMC4972181. 4. Coles JA, Myburgh E, Ritchie R, Hamilton A, Rodgers J, Mottram JC, Barrett MP, Brewer JM. Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Negl Trop Dis. 2015 Apr 16;9(4):e0003714. doi: 10.1371/journal.pntd.0003714. eCollection 2015 Apr. PubMed PMID: 25881126; PubMed Central PMCID: PMC4400075.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Furamidine dihydrochloride 55368-40-6 Furamidine Dihydrochloride Furamidine DB 75, DB75, NSC 305831, WR199385 DB 75, DB75, NSC 305831, WR-199385 Furamidine HCl DB 75, DB75, NSC 305831, WR 199385 inhibitor inhibit

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