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Lofepramine hydrochloride

Catalog No. T24414 CAS 26786-32-3

Synonyms: WHR-2908A, DB-2182, WHR 2908A

Lofepramine is a serotonin and norepinephrine reuptake inhibitor. Lofepramine is also a psychotropic IMIPRAMINE derivative.

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Lofepramine hydrochloride Chemical Structure

Lofepramine hydrochloride, CAS 26786-32-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Lofepramine is a serotonin and norepinephrine reuptake inhibitor. Lofepramine is also a psychotropic IMIPRAMINE derivative.

Synonyms	WHR-2908A, DB-2182, WHR 2908A
Molecular Weight	455.42
Formula	C26H28Cl2N2O
CAS No.	26786-32-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lancaster SG, Gonzalez JP. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40. Review. PubMed PMID: 2649353. 2. Herdman JR, Cowen PJ, Campling GM, Hockney RA, Laver D, Sharpley AL. Effect of lofepramine on 5-HT function and sleep. J Affect Disord. 1993 Sep;29(1):63-72. PubMed PMID: 8254146. 3. Feighner JP, Meridith CH, Dutt JE, Hendrickson GG. A double blind comparison of lofepramine, imipramine and placebo in patients with depression. Acta Psychiatr Scand. 1982 Aug;66(2):100-8. PubMed PMID: 6753500. 4. Hopes H. Effects of lofepramine on human sleep: a pilot study. Int Clin Psychopharmacol. 1989 Oct;4(4):295-300. PubMed PMID: 2607127.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lofepramine hydrochloride 26786-32-3 WHR-2908A DB2182 DB-2182 DB 2182 WHR 2908A Lofepramine Hydrochloride inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.