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DBCO-S-S-PEG3-biotin

Catalog No. T15076 CAS 1430408-09-5

DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DBCO-S-S-PEG3-biotin, CAS 1430408-09-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00

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Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.
In vitro	PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	869.12
Formula	C42H56N6O8S3
CAS No.	1430408-09-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Related compound libraries

This product is contained In the following compound libraries：

Covalent Inhibitor Library Cysteine Covalent Library

Related Products

Related compounds with same targets

Fmoc-N-PEG7-acid Alkynyl Palmitic Acid Azido-PEG2-azide m-PEG8-O-alkyne Br-C10-methyl ester Amine-PEG-CH2COOH (MW 2000) Monoethyl pimelate 2-Phthalimidehydroxy-acetic acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DBCO-S-S-PEG3-biotin 1430408-09-5 Others PROTAC PROTAC Linker inhibit PROTAC Linkers DBCO-S-S-PEG-3-biotin Inhibitor DBCOSSPEG3biotin DBCO S S PEG3 biotin inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.