β-nm — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4721	β-Nicotinamide mononucleotide	β-NM	Others , Endogenous Metabolite
	β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD...		Others , Endogenous Metabolite
T63516	NRX-252114	NRX252114,NRX 252114	Wnt/beta-catenin
	NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-...		Wnt/beta-catenin
T63427	NRX-103094	NRX103094,NRX 103094	Wnt/beta-catenin
	NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.		Wnt/beta-catenin
T13477	β-Glucuronidase-IN-1		Antibacterial
	β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuron...		Antibacterial
T9182	NRX-252262		Others , Wnt/beta-catenin
	NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50：3.8 nM)		Others , Wnt/beta-catenin
T4043	ETC-159	ETC159,ETC-1922159,ETC 159	Wnt/beta-catenin , Porcupine
	ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.		Wnt/beta-catenin , Porcupine
T16094	MK-3328		Others
	MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.		Others
T6118	NVP-HSP990	HSP990	Apoptosis , HSP
	NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).		Apoptosis , HSP
T2639	LY2811376		Beta Amyloid , Beta-Secretase , BACE
	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...		Beta Amyloid , Beta-Secretase , BACE
T23434	GPR35 agonist 2	TC-G 1001	GPR , Arrestin
	GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respectively.		GPR , Arrestin
T1989	Luminespib	AUY922,VER-52296,NVP-AUY922	Apoptosis , HSP , Autophagy
	Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).		Apoptosis , HSP , Autophagy
T12997	SR-318		p38 MAPK , TNF
	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity.		p38 MAPK , TNF
T15429	GSK2194069		Others , NADPH , Fatty Acid Synthase
	GSK2194069 is an active β-keto reductase (KR)-specific inhibitor of fatty acid synthase (FASN) with an IC50 of 7.7 nM in an assay for the detection of released CoA.GSK2194069 inhibits the proliferation of FAS in cancer c...		Others , NADPH , Fatty Acid Synthase
T18887	4-Methylumbelliferyl-β-D-glucuronide hydrate	MUG	Others
	4-Methylumbelliferyl-β-D-glucuronide hydrate (MUG) is a fluorogenic substrat (λex=362 nm , λem=445 nm).		Others
T4201	Avibactam sodium	AVE-1330A,NXL-104	Antibacterial , Antibiotic
	Avibactam sodium (NXL-104) is a reversible β-lactamase inhibitor (IC50: 8/80/38 nM, for TEM-1/P99/KPC-2 β-lactamases).		Antibacterial , Antibiotic
T1917	GSK 3 Inhibitor IX	BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis , GSK-3 , Tyrosine Kinases , CDK
	GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively.		Apoptosis , GSK-3 , Tyrosine Kinases , CDK
T30846	CGP-20712	UNII-SIO2UEZ19H,CGP 20712	Adrenergic Receptor
	CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.		Adrenergic Receptor
T63730	NRX-103095		Wnt/beta-catenin
	NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.		Wnt/beta-catenin
T3077	SB 216763	SB216763	GSK-3 , Autophagy
	SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).		GSK-3 , Autophagy
T6306	Erteberel	LY500307	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor