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MK-3328

Catalog No. T16094 CAS 1201323-97-8

MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.

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MK-3328, CAS 1201323-97-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 99.82%

Purity: 98.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease.
Targets&IC50	β-Amyloid:10.5 nM
In vitro	MK-3328 displays amyloid binding potency balanced with low levels of nonspecific binding.[1]
In vivo	In normal rhesus monkey positron emission tomography (PET) imaging studies, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake, and good washout.[2]

Molecular Weight	268.25
Formula	C14H9FN4O
CAS No.	1201323-97-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: <10mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011;2(7):498-502.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Clinical Compound Library Neuronal Signaling Compound Library Bioactive Compound Library

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Keywords

MK-3328 1201323-97-8 Others MK3328 MK 3328 inhibitor inhibit

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