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ETC-159

Catalog No. T4043 CAS 1638250-96-0

Synonyms: ETC159, ETC 159, ETC-1922159

ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

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ETC-159, CAS 1638250-96-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
Targets&IC50	β-catenin:2.9 nM.

Synonyms	ETC159, ETC 159, ETC-1922159
Molecular Weight	391.391
Formula	C19H17N7O3
CAS No.	1638250-96-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Madan B, et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene. 2015 Aug 10. doi: 10.1038/onc.2015.280.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Cancer Cell Differentiation Compound Library Anti-Obesity Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Neural Regeneration Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Breast Cancer Compound Library Stem Cell Differentiation Compound Library

Related Products

Related compounds with same targets

IWP-O1 Porcn-IN-1 ETC-159 IWP-2 IWP L6 LGK974 Wnt-C59 GNF-6231

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ETC-159 1638250-96-0 干细胞细胞骨架 Porcupine Wnt/beta-catenin ETC1922159 ETC 1922159 ETC159 Inhibitor inhibit Wnt ETC-1922159 ETC 159 inhibitor

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