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β-Nicotinamide mononucleotide

Catalog No. T4721 CAS 1094-61-7

Synonyms: β-NM

β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=< Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions.

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β-Nicotinamide mononucleotide Chemical Structure

β-Nicotinamide mononucleotide, CAS 1094-61-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 46.00
25 mg	In stock	$ 71.00
50 mg	In stock	$ 108.00
100 mg	In stock	$ 153.00
500 mg	In stock	$ 377.00
1 g	In stock	$ 558.00

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Purity: 100%

Purity: 99.66%

Purity: 98.18%

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Description

β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=> Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions.

Synonyms	β-NM
Molecular Weight	334.22
Formula	C11H15N2O8P
CAS No.	1094-61-7

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Ohdoi C, et al. Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 15;792(1):123-30.

Citations

1. Xu B, Zhang P, Tang X, et al. Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. Advanced Science. 2022: 2204697. 2. Zhao S, Hong Y, Liang Y, et al. Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast. Redox biology. 2022, 55: 102414.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Human Endogenous Metabolite Library Natural Product Library RO5 Drug-like Natural Product Library Human Metabolite Library Human Endogenous Metabolite Compound Library Plus Natural Product Library for HTS Nucleotide Compound Library Mouse Metabolite Compound Library

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Keywords

β-Nicotinamide mononucleotide 1094-61-7 Metabolism Others Endogenous Metabolite Alzheimer's inhibit obesity NMN b-NM β-NM Inhibitor intermediate diabetes NAD cardioprotection b-Nicotinamide mononucleotide cancer βNicotinamide mononucleotide β Nicotinamide mononucleotide beta-Nicotinamide mononucleotide beta-NM disease inhibitor

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