Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 139.00 | |
25 mg | In stock | $ 233.00 | |
50 mg | In stock | $ 347.00 | |
100 mg | In stock | $ 516.00 | |
500 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase. |
Targets&IC50 | β-glucuronidase (E. coli):283 nM , β-glucuronidase (E. coli):283 nM, β-glucuronidase (E. coli):164 nM(Ki) |
In vitro |
β-Glucuronidase-IN-1 (0.01-100 μM) inhibits E. coli β-glucuronidase activity in a dose-dependent manner(IC50 and Ki of 283 nM and 164 nM, respectively).[1] β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells with EC50 of 17.7 nM.[1] |
In vivo | β-Glucuronidase-IN-1 (10 μg; oral gavage; twice per day; 11 days) shields the gastrointestinal epithelium of mice from damage induced by CPT-11, preserving the glandular structure in the treated intestinal tissues.[1] |
Molecular Weight | 425.54 |
Formula | C23H27N3O3S |
CAS No. | 484006-66-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (70.5 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
β-Glucuronidase-IN-1 484006-66-8 Microbiology/Virology Antibacterial beta-Glucuronidase-IN-1 β Glucuronidase IN 1 b-Glucuronidase-IN-1 βGlucuronidaseIN1 inhibitor inhibit