stimulated — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38361	GSK717		IL Receptor , NOD
	GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio...		IL Receptor , NOD
T4592	TOMATIDINE HYDROCHLORIDE	Tomatidine,Tomatidine HCl	Others , NF-κB , JNK , Autophagy
	Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatid...		Others , NF-κB , JNK , Autophagy
T1286	Vincamine	Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval	GPR , Others
	Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.		GPR , Others
T14204	6-Iodopravadoline	AM630	Cannabinoid Receptor
	6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.		Cannabinoid Receptor
T2755	Rhoifolin	Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy
	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
T7144	BTS	N-Tosylbenzylamine,N-Benzyl-p-toluenesulfonamide	ATPase , Myosin
	BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .		ATPase , Myosin
TP1916L1	[D-Phe12,Leu14]-Bombesin acetate	[D-Phe12,Leu14]-Bombesin acetate(108437-88-3 Free base)	Bombesin Receptor
	[D-Phe12,Leu14]-Bombesin acetate inhibits bombesin-stimulated secretion.		Bombesin Receptor
TP2239L	[D-Phe12]-Bombesin acetate	[D-Phe12]-Bombesin acetate(108437-87-2 free base)	Bombesin Receptor
	[D-Phe12]-Bombesin acetate inhibits bombesin-stimulated secretion.		Bombesin Receptor
T6S1543	Dehydrodiisoeugenol		Others , NF-κB , COX , Antibacterial
	1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...		Others , NF-κB , COX , Antibacterial
T38612	Linaprazan glurate		Others
	Linaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate can be used in studies about gastrointestinal inflammatory diseases and peptic ulcer diseases.		Others
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
T27850	LP-471756	LP471756	GPR
	LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).		GPR
T3543	NS-638	NS 638	Calcium Channel
	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).		Calcium Channel
TP2036L	DPDPE TFA (88373-73-3 free base)	DPDPE TFA	Opioid Receptor
	DPDPE TFA is selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.		Opioid Receptor
T2S0765	Epibetulinic acid		NO Synthase , Prostaglandin Receptor
	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.		NO Synthase , Prostaglandin Receptor
T3039	Hederagenin	Hederagenic acid,Astrantiagenin E,Caulosapogenin,Hederagenol	Others
	Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.		Others
T3635	IQ 1	IQ1,IQ-1	Wnt/beta-catenin
	IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.		Wnt/beta-catenin
T4278	AM966		LPA Receptor , LPL Receptor
	AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.		LPA Receptor , LPL Receptor
TP2092L	Apelin-17 (human, bovine) acetate	Apelin-17 (human, bovine) acetate(217082-57-0 free base)	HIV Protease
	Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).		HIV Protease