metabolite，liver — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11428	Glyco-Obeticholic acid		FXR
	Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).		FXR
T13092	Tauro-Obeticholic acid		FXR
	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).		FXR
TQ0274	27-Hydroxycholesterol	25(R)-27-hydroxy Cholesterol	Estrogen/progestogen Receptor , Liver X Receptor
	27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.		Estrogen/progestogen Receptor , Liver X Receptor
T3424	Ezutromid	BMN 195,VOX-C1100,SMT C1100	Others
	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ...		Others
T7475	S-Adenosyl-L-methionine	AdoMet,Ademetionine,SAMe,S-Adenosyl methionine	Others , Endogenous Metabolite
	S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.		Others , Endogenous Metabolite
T20366	Beta-Nicotyrine	Nicotyrine,alpha-Nicotyrine	Others
	beta-Nicotyrine is a tobacco alkaloids Metabolite in the liver.		Others
T1645	Ramipril	HOE-498,Tritace,Altace,Carasel	Apoptosis , RAAS
	Ramipril (Altace) is a long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.		Apoptosis , RAAS
T37683	3-Hydroxykynurenine	3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.		Others
T5873	2,6-Dihydroxybenzoic acid		Endogenous Metabolite
	2,6-Dihydroxybenzoic acid, a secondary metabolite derived from salicylic acid, undergoes hydrolyzation by liver enzymes as part of phase I metabolism.		Endogenous Metabolite
T5233	N-Methylnicotinamide	N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide	Others , Endogenous Metabolite
	N-Methylnicotinamide (Nicotinic Acid Methylamide) is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-Methylnicotinamide (Nicotinic Acid Methylam...		Others , Endogenous Metabolite
T0738	Urea	Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide	Others , DHFR , Wnt/beta-catenin , Arginase , Endogenous Metabolite , Carbonic Anhydrase
	Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids.
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T0255	Clomipramine hydrochloride	Clomipramine HCl,Anafranil	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine , GST
	Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth...
T4876	2-(1H-Indol-3-yl)ethan-1-ol	Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol	Others , Endogenous Metabolite
	2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.		Others , Endogenous Metabolite
T0617	Nicotinamide N-oxide	Nicotinamide-N-oxide,Nicotinamide 1-oxide,1-oxynicotinamide	c-Myc , Endogenous Metabolite , CXCR , Drug Metabolite
	Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of n...		c-Myc , Endogenous Metabolite , CXCR , Drug Metabolite
T0109	Molsidomine	Morsydomine,SIN-10,Corvaton	NOD
	Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.		NOD
T0816	Acetohexamide	Acetohexamid,Dymelor,Gamadiabet	Potassium Channel , NADPH
	Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) wi...		Potassium Channel , NADPH
T1705	5-Amino-3H-imidazole-4-Carboxamide	4-Amino-5-imidazolecarboxamide,AICA,5-Aminoimidazole-4-carboxamide	Endogenous Metabolite
	5-Amino-3H-imidazole-4-Carboxamide (AICA) is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparat...		Endogenous Metabolite
T13979	(S)-3-Hydroxybutanoic acid	L-β-Hydroxybutyric acid,(S)-β-Hydroxybutanoic acid,L-(+)-3-Hydroxybutyric acid	Endogenous Metabolite
	(S)-3-Hydroxybutanoic acid (L-(+)-3-Hydroxybutyric acid) is a normal human metabolite that has been found elevated in geriatric patients remitting from depression. (S)-3-Hydroxybutanoic acid is synthesized in the liver f...		Endogenous Metabolite
T5306	H-Abu-OH	L-Aminobutyric Acid,L-α-amino-n-Butyric acid,L(+)-2-Aminobutyric acid	Others , Endogenous Metabolite
	H-Abu-OH (L-α-amino-n-Butyric acid) , also known as (S)-2-aminobutanoic acid, homoalanine, 2-AABA, ethylglycine, or L-butyrine, is a member of the class of compounds known as L-alpha-amino acids. H-Abu-OH is a non-proteo...		Others , Endogenous Metabolite