Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 29.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide. |
Targets&IC50 | SUR1:22.9 µM(Ki), KIR6.2:14.2 µM(Ki) |
Synonyms | Acetohexamid, Dymelor, Gamadiabet |
Molecular Weight | 324.4 |
Formula | C15H20N2O4S |
CAS No. | 968-81-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (92.48 mM)
You can also refer to dose conversion for different animals. More
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Acetohexamide 968-81-0 Membrane transporter/Ion channel Metabolism Potassium Channel NADPH Acetohexamid inhibit Dymelor Inhibitor Gamadiabet inhibitor