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Clomipramine hydrochloride

Name: Clomipramine hydrochloride
Brand: TargetMol
SKU: T0255
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0255Cas No. 17321-77-6

Alias Clomipramine HCl, Anafranil

Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Clomipramine hydrochloride

🥰Excellent

Purity: 99.47%

Catalog No. T0255Alias Clomipramine HCl, AnafranilCas No. 17321-77-6

Pack Size	Price	Availability
200 mg	$30	In Stock
500 mg	$40	In Stock
1 g	$56	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.47%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Targets&IC50	NET:54 nM(Ki), Dopamine transporter:3 nM(Ki), SERT:0.14 nM(Ki)
Synonyms	Clomipramine HCl, Anafranil

Chemical Properties

Molecular Weight	351.31
Formula	C₁₉H₂₃ClN₂·HCl
Cas No.	17321-77-6
Smiles	Cl.CN(C)CCCN1c2ccccc2CCc2c1cc(Cl)cc2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 142.32 mM, Sonication is recommended.

DMSO: 7.5 mg/mL (21.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.8465 mL	14.2324 mL	28.4649 mL	142.3244 mL
5 mM	0.5693 mL	2.8465 mL	5.6930 mL	28.4649 mL
10 mM	0.2846 mL	1.4232 mL	2.8465 mL	14.2324 mL
20 mM	0.1423 mL	0.7116 mL	1.4232 mL	7.1162 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0569 mL	0.2846 mL	0.5693 mL	2.8465 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4232 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc