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Clomipramine hydrochloride

Clomipramine hydrochloride
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Catalog No. T0255Cas No. 17321-77-6
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Purity:99.47%
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Clomipramine hydrochloride

Catalog No. T0255Cas No. 17321-77-6
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
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Pack SizePriceAvailabilityQuantity
25 mg$32In Stock
50 mg$40In Stock
100 mg$50In Stock
200 mg$62In Stock
500 mg$82In Stock
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Product Introduction

Bioactivity
Description
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
Targets&IC50
NET:54 nM(Ki), Dopamine transporter:3 nM(Ki), SERT:0.14 nM(Ki)
AliasClomipramine HCl, Anafranil
Chemical Properties
Molecular Weight351.31
FormulaC19H23ClN2·HCl
Cas No.17321-77-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 142.32 mM
DMSO: 7.5 mg/mL (21.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.8465 mL14.2324 mL28.4649 mL142.3244 mL
5 mM0.5693 mL2.8465 mL5.6930 mL28.4649 mL
10 mM0.2846 mL1.4232 mL2.8465 mL14.2324 mL
20 mM0.1423 mL0.7116 mL1.4232 mL7.1162 mL
H2O
1mg5mg10mg50mg
50 mM0.0569 mL0.2846 mL0.5693 mL2.8465 mL
100 mM0.0285 mL0.1423 mL0.2846 mL1.4232 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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