Powder: -20°C for 3 years | In solvent: -80°C for 1 year
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 172.00 | |
10 mg | In stock | $ 255.00 | |
25 mg | In stock | $ 433.00 | |
50 mg | In stock | $ 628.00 |
Description | 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
In vitro | 27-Hydroxycholesterol activates estrogen receptors, adversely impacting prostate cancer cell lines by significantly enhancing cell proliferation in LNCaP and PC3 cells. This proliferation can be mitigated by estrogen receptor inhibitors [1]. As an endogenous selective estrogen receptor modulator, 27-Hydroxycholesterol exhibits substantial partial agonist activity across various cellular models, notably increasing gene transcription and cell proliferation in breast cancer contexts [2]. Produced from cholesterol by the enzyme CYP27A1, it plays a vital role in regulating intracellular cholesterol equilibrium. Its pro-tumorigenic effects can be diminished by either statins or directly inhibiting CYP27A1 [3]. Furthermore, 27-Hydroxycholesterol's conversion from cholesterol is crucial for LXR activation when faced with cholesterol excess [4]. |
Synonyms | 25(R)-27-hydroxy Cholesterol |
Molecular Weight | 402.65 |
Formula | C27H46O2 |
CAS No. | 20380-11-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 2mg/mL (4.97 mM)
DMSO: 0.1mg/mL
Ethanol: ≤ 20 mg/mL (49.66 mM)
You can also refer to dose conversion for different animals. More
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27-Hydroxycholesterol 20380-11-4 Endocrinology/Hormones Metabolism Estrogen/progestogen Receptor Liver X Receptor 27Hydroxycholesterol LXR Liver X receptor Inhibitor Estrogen Receptor/ERR Endogenous Metabolite 27 Hydroxycholesterol 2527-hydroxy Cholesterol 25(R)-27-hydroxy Cholesterol inhibit inhibitor