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Molsidomine

Molsidomine
Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
Catalog No. T0109Cas No. 25717-80-0
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Molsidomine

Catalog No. T0109Cas No. 25717-80-0
Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
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Pack SizePriceAvailabilityQuantity
200 mg$32In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
In vivo
Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1].
AliasMorsydomine, SIN-10, Corvaton
Chemical Properties
Molecular Weight242.23
FormulaC9H14N4O4
Cas No.25717-80-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (185.8 mM)
H2O: 9 mg/mL (37.15 mM)
Ethanol: 21 mg/mL (86.7 mM)
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.1283 mL20.6415 mL41.2831 mL206.4154 mL
5 mM0.8257 mL4.1283 mL8.2566 mL41.2831 mL
10 mM0.4128 mL2.0642 mL4.1283 mL20.6415 mL
20 mM0.2064 mL1.0321 mL2.0642 mL10.3208 mL
Ethanol/DMSO
1mg5mg10mg50mg
50 mM0.0826 mL0.4128 mL0.8257 mL4.1283 mL
DMSO
1mg5mg10mg50mg
100 mM0.0413 mL0.2064 mL0.4128 mL2.0642 mL

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