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Molsidomine

Name: Molsidomine
Brand: TargetMol
SKU: T0109
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0109Cas No. 25717-80-0

Alias SIN-10, Morsydomine, Corvaton

Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

Molsidomine

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Purity: 99.98%

Catalog No. T0109Alias SIN-10, Morsydomine, CorvatonCas No. 25717-80-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
In vivo	Molsidomine (50, 100, 250 μg/kg) reduces coronary flow while the coronary resistance remains unaffected by molsidomine. Molsidomine decreases myocardial oxygen consumption. Heart rate and contractility remains unchanged by molsidomine. Stroke volume and cardiac output fall after molsidomine. The fall in blood pressure after molsidomine follows the reduction in cardiac output as sequel of lowered preload and venous return to the heart[1].
Synonyms	SIN-10, Morsydomine, Corvaton

Chemical Properties

Molecular Weight	242.23
Formula	C₉H₁₄N₄O₄
Cas No.	25717-80-0
Smiles	[N-](C(OCC)=O)C1=C[N+](=NO1)N2CCOCC2
Relative Density.	1.3186 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (185.77 mM), Sonication is recommended.

H2O: 9 mg/mL (37.15 mM), Sonication is recommended.

Ethanol: 21 mg/mL (86.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1283 mL	20.6415 mL	41.2831 mL	206.4154 mL
5 mM	0.8257 mL	4.1283 mL	8.2566 mL	41.2831 mL
10 mM	0.4128 mL	2.0642 mL	4.1283 mL	20.6415 mL
20 mM	0.2064 mL	1.0321 mL	2.0642 mL	10.3208 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0826 mL	0.4128 mL	0.8257 mL	4.1283 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc