esophageal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8796	CAN508		CDK
	CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...		CDK
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T7322	Theliatinib		EGFR
	Theliatinib, a potent and highly selective EGFR inhibitor, with anti-tumor activity. Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively.		EGFR
T0992	Carbenoxolone disodium	Biogastrone,Duogastrone,Bioral	Gap Junction Protein
	Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ...		Gap Junction Protein
T0866	Propafenone	Rythmol,Propafenonum	Potassium Channel , MRP , Sodium Channel
	Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....		Potassium Channel , MRP , Sodium Channel
T11918	Lysipressin	Lysine vasopressin,[Lys8]-Vasopressin	Others
	Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.		Others
T6S1844	Tenacissoside H	Tenacissimoside C	Others
	Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.		Others
T0044	Oxethazaine	Oxetacaine	HBV , Sodium Channel
	Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.		HBV , Sodium Channel
T8341	QX 314	QX-314	Others
	QX 314 (Lidocaine N-ethyl bromide) is a blocker of non-membrane-permeable,and Inhibits Acid-Induced Activation of Esophageal Nociceptive C Fiber Neurons.		Others
T39640	JAB-3068	SHP2-IN-6	Phosphatase
	JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor with anticancer and antitumor activity for the study of breast, lung, and esophageal cancers.		Phosphatase
T4S1796	Heterophyllin B		PI3K
	Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa...		PI3K
T6136	Canertinib	PD-183805,CI-1033	EGFR
	Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp...		EGFR
T24610	Pegamotecan	Prothecan,PEG-camptothecin,PEG-beta-CPT	Topoisomerase
	Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung and pancreatic cancers.		Topoisomerase
T76717	Serplulimab	HLX 10	COX
	Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma.		COX
T38387	Compound C108		GTPase
	Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.		GTPase
T35394	Sintilimab (anti-PD-1)	IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1
	Sintilimab (IBI308) is a humanized IgG4 monoclonal antibody with significant anti-tumor activity that restores endogenous anti-tumor T-cell responses by binding to PD-1 and thereby blocking the interaction of PD-1 with i...		PD-1/PD-L1
T1291	Cisapride	Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase	Potassium Channel , 5-HT Receptor , HER
	Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease...		Potassium Channel , 5-HT Receptor , HER
T61699	Osunprotafib	AC 484,Osunprotafib,AC484,ABBV-CLS-484	Phosphatase
	ABBV-CLS-484 (Osunprotafib) is a potent PTPN2 inhibitor with subnanomolar activity and antitumor activity that enhances T-cell anti-tumor immunity.ABBV-CLS-484 can be used for the treatment of neoplasms, esophageal cance...		Phosphatase
TN1721	Gypenoside L		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS