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Cisapride

Catalog No. T1291   CAS 81098-60-4
Synonyms: Prepulsid, R 51619, Pridesia, Kaudalit, (±)-Cisaprid, Kinestase

Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.

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Cisapride Chemical Structure
Cisapride, CAS 81098-60-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 54.00
25 mg In stock $ 70.00
50 mg In stock $ 100.00
100 mg In stock $ 137.00
200 mg In stock $ 247.00
500 mg In stock $ 415.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.5%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux.
Targets&IC50 ERG channel (human):9.4 nM, 5-HT4 receptor:140 nM(EC50)
In vitro Cisapride inhibits vascular Kv current independently of serotonin 5-HT4-receptor activation[2]. As HERG channel blocker, cisapride, can inhibit the growth of gastric cancer cells by altering distribution of cell cycle and inducing apoptosis so as to be of potential value in the treatment of gastric cancer. Cisapride could inhibit the growth and clonogenicity of human gastric cancer lines by specific blockage of HERG channel in a time- and dose-dependent manner while has little effects on GES cells[3].
Cell Research Cells in the logarithmic growth phase are harvested and seeded in 96-well plates. The cell number is diluted to 5000/well in 200 microliters of RPMI1640 medium. In vitro experiments are carried out on the gastric cancer cell lines and GES cell line, using an MTT proliferation assay. MTT stains live cells, and the optical density absorbance at 490 nM wavelength correlates with the cell number. Cisapride is added to the cells at concentrations of 0, 12.5, 25, 50, 100 or 200 nM and equivalent volume of ethanol is added as control in order to eliminate the effects of solvent. Twenty microliters of MTT is added to each well of the cell culture 4 h before termination of the culture at 37?C. One hundred and fifty microliters of dimethyl sulfoxide is added to each well at the end of the culture and the plate is agitated for 10 minutes. The absorbency at 490 nm is read by a BIOHIT BP800 plate reader. Growth curve is drawn according to MTT colorimetry. The inhibition rate is calculated.(Only for Reference)
Synonyms Prepulsid, R 51619, Pridesia, Kaudalit, (±)-Cisaprid, Kinestase
Molecular Weight 465.95
Formula C23H29ClFN3O4
CAS No. 81098-60-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 46.6 mg/mL(100 mM)

TargetMolReferences and Literature

1. Park JS, et al. Eur J Med Chem. 2016, 109:75-88. 2. Kim HW, et al.Biochem Biophys Res Commun. 2016, 478(3):1423-8. 3. Shao XD, et al. Cancer Biol Ther. 2005, 4(3):295-301.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Approved Drug Library Anti-Lung Cancer Compound Library

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Keywords

Cisapride 81098-60-4 Angiogenesis GPCR/G Protein JAK/STAT signaling Membrane transporter/Ion channel Neuroscience Tyrosine Kinase/Adaptors Potassium Channel 5-HT Receptor HER 5-hydroxytryptamine Receptor R51619 prokinetic agent 5-HT4 agonist hERG Inhibitor patch-clamp Serotonin Receptor inhibit Prepulsid R 51619 Pridesia Kaudalit (±)-Cisaprid Cisaprid gastrointestinal Kinestase R-51619 inhibitor

 

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