efficacious — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7121	Sulfaclozine	Sulfachloropyrazine,Sulfachloropyrazine sodium	Antibacterial , Antibiotic , Parasite
	Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects		Antibacterial , Antibiotic , Parasite
T16501	PF-3644022		p38 MAPK , Serine Protease , MAPK
	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib...		p38 MAPK , Serine Protease , MAPK
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T3544	SHP099 hydrochloride		Phosphatase , Others
	SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.		Phosphatase , Others
T14217	AMG 579	AMG-579	PDE
	AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).		PDE
T12462	PI3Kδ-IN-1		PI3K
	PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).		PI3K
T3692	GNE-477	GNE 477	PI3K , mTOR
	GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.		PI3K , mTOR
T2338	JZL195		FAAH , Lipase , Autophagy
	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.		FAAH , Lipase , Autophagy
T36526	IL-17 modulator 4		Interleukin
	IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17.		Interleukin
T6148	CX-6258 hydrochloride	CX-6258 HCl,Pim-Kinase Inhibitor X	Pim
	CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).		Pim
T3741	(-)-borneol	L-Borneol	GABA Receptor
	(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.		GABA Receptor
T4690	Betrixaban hydrochloride(330942-05-7(free base))	PRT054021 hydrochloride	Factor Xa
	Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM).		Factor Xa
T16996	TAS6417		Apoptosis , EGFR
	TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).		Apoptosis , EGFR
T14302	Olorinab	APD 371	Cannabinoid Receptor
	Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.		Cannabinoid Receptor
T12181	NaV1.7 inhibitor-1		Sodium Channel
	NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).		Sodium Channel
T2030	Tiplaxtinin	PAI-039,Tiplasinin	PAI-1 , Apoptosis
	Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.		PAI-1 , Apoptosis
T28073	MLS1547	MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor
	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa...		Dopamine Receptor
T11980	MD-224		Mdm2 , E1/E2/E3 Enzyme , PROTACs
	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.		Mdm2 , E1/E2/E3 Enzyme , PROTACs
T14087	ABT-239		TRP/TRPV Channel
	ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists. It also acts as a transient receptor potential vanilloid type 1 (TRPV1) antagonist.		TRP/TRPV Channel
T12165	NAChR agonist 1	DUN71755	AChR
	nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.		AChR