Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 59.00 | |
25 mg | In stock | $ 88.00 | |
50 mg | In stock | $ 123.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay. |
In vitro | MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay. MLS1547 is found to completely displace [3H]methylspiperone binding to the D2 dopamine receptor, with a calculated Ki of 1.2 μM[2]. |
Synonyms | MLS000051547, MLS 1547, MLS-1547 |
Molecular Weight | 354.83 |
Formula | C19H19ClN4O |
CAS No. | 315698-36-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (126.82 mM)
You can also refer to dose conversion for different animals. More
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MLS1547 315698-36-3 GPCR/G Protein Neuroscience Dopamine Receptor MLS-000051547 Inhibitor inhibit biased β-arrestin MLS000051547 MLS 000051547 MLS 1547 protein signaling MLS-1547 recruitment inhibitor